740 Y-P

Name: 740 Y-P
Brand: Tocris Bioscience
SKU: 1983
Rating: 3 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1983

(1)

Citations (60)

COA / SDS

Cell-permeable PI 3-kinase activator

Key Product Details

Description:	Cell-permeable PI 3-kinase activator
Alternative Names:	PDGFR⁷⁴⁰Y-P
Purity:	≥85% (HPLC)
Molecular Weight:	3270.72

View Full Technical Details for 740 Y-P

Technical Data
Citations / Reviews (1)

Biological Activity for 740 Y-P

740 Y-P is a cell-permeable phosphopeptide activator of PI 3-kinase. Binds with high affinity to p85 subunit of the enzyme. Displays mitogenic activity in C2 muscle cells and promotes survival of rat cerebellar granule neurons in vitro.

Technical Data for 740 Y-P

M. Wt	3270.72
Formula	C₁₄₁H₂₂₂N₄₃O₃₉PS₃
Single Letter Sequence	RQIKIWFQNRRMKWKKSDGGYMDMS (Modifications: Tyr-21 = pTyr)
Storage	Store at -20°C
Purity	≥85% (HPLC)
CAS Number	1236188-16-1
PubChem ID	90488730
InChi Key	XCGMILZGRGEWHL-QYGSNONCSA-N
Smiles	[H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=C(OP(O)(O)=O)C=C1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 740 Y-P

Solubility

Soluble to 1mg/ml in water

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References for 740 Y-P

References are publications that support the biological activity of the product.

Derossi Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide. Biochem.Biophys.Res.Comm.
Williams and Doherty Evidence for and against a pivotal role of PI 3-kinase in a neuronal cell survival pathway. Mol.Cell.Neurosci. 1999 PMID: 10328886