7rh

Name: 7rh
Brand: Tocris Bioscience
SKU: 5860

Tocris Bioscience, part of Bio-Techne | Catalog # 5860

Citations (3)

COA / SDS

Potent and selective DDR1 inhibitor; orally bioavailable

Key Product Details

Description:	Potent and selective DDR1 inhibitor; orally bioavailable
Chemical Name:	4-Ethyl-N-[3-[(4-methyl-1-piperazinyl)methyl]-5-(trifluoromethyl)phenyl]-3-(2-pyrazolo[1,5-a]pyrimidin-6-ylethynyl)benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	546.59

View Full Technical Details for 7rh

Technical Data
Citations

Biological Activity for 7rh

7rh is a potent and selective DDR1 inhibitor (IC₅₀ = 6.8 nM). Exhibits selectivity for DDR1 over DDR2, Bcr-Abl and c-Kit (IC₅₀ values are 101.4 and 355 nM and > 10 μM, respectively) and a range of other kinases. Inhibits proliferation of cancer cell lines expressing high levels of DDR1 in vitro and suppresses cancer cell invasion, adhesion and tumorigenicity. Orally bioavailable.

Technical Data for 7rh

M. Wt	546.59
Formula	C₃₀H₂₉F₃N₆O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1429617-90-2
PubChem ID	71550931
InChi Key	DDLPXZXBWGJRGK-UHFFFAOYSA-N
Smiles	O=C(NC1=CC(CN2CCN(C)CC2)=CC(C(F)(F)F)=C1)C3=CC(C#CC(C=N4)=CN5C4=CC=N5)=C(CC)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 7rh

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	54.66	100

Preparing Stock Solutions for 7rh

The following data is based on the product molecular weight 546.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.83 mL	9.15 mL	18.30 mL
5 mM	0.37 mL	1.83 mL	3.66 mL
10 mM	0.18 mL	0.91 mL	1.83 mL
50 mM	0.04 mL	0.18 mL	0.37 mL

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References for 7rh

References are publications that support the biological activity of the product.

Gao Discovery and optimization of 3-(2-(pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as novel selective and orally bioavailable discoidin domain receptor 1 (DDR1) inhibitors. J.Med.Chem. 2013 PMID: 23521020

7rh