8-Azaadenosine

Name: 8-Azaadenosine
Brand: Tocris Bioscience
SKU: 6868

Tocris Bioscience, part of Bio-Techne | Catalog # 6868

COA / SDS

ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor; inhibits leukemia stem cell self-renewal

Key Product Details

Description:	ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor; inhibits leukemia stem cell self-renewal
Chemical Name:	3-β-D-Ribofuranosyl-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine
Purity:	≥98% (HPLC)
Molecular Weight:	268.23

View Full Technical Details for 8-Azaadenosine

Technical Data
Citations

Biological Activity for 8-Azaadenosine

8-Azaadenosine is an ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor. Reduces A-to-I editing activity in a leukemia cell line, restores let-7 and inhibits leukemia stem cells self-renewal in vitro.

Compound Libraries for 8-Azaadenosine

8-Azaadenosine is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for 8-Azaadenosine

M. Wt	268.23
Formula	C₉H₁₂N₆O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	10299-44-2
PubChem ID	96410
InChi Key	OAUKGFJQZRGECT-UUOKFMHZSA-N
Smiles	NC1=NC=NC2=C1N=NN2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 8-Azaadenosine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	26.82	100

Preparing Stock Solutions for 8-Azaadenosine

The following data is based on the product molecular weight 268.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.73 mL	18.64 mL	37.28 mL
5 mM	0.75 mL	3.73 mL	7.46 mL
10 mM	0.37 mL	1.86 mL	3.73 mL
50 mM	0.07 mL	0.37 mL	0.75 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for 8-Azaadenosine

References are publications that support the biological activity of the product.

Zhang and Slack ADARs edit microRNAs to promote leukemic stem cell activity. Cell Stem Cell 2016 PMID: 27494666
Zipeto ADAR1 activation drives leukemia stem cell self-renewal by impairing let-7 biogenesis. Cell Stem Cell 2016 PMID: 27292188