8MDP

Name: 8MDP
Brand: Tocris Bioscience
SKU: 4588

Tocris Bioscience, part of Bio-Techne | Catalog # 4588

Citations (1)

COA / SDS

Potent equilibrative nucleoside transporter (ENT) inhibitor

Key Product Details

Description:	Potent equilibrative nucleoside transporter (ENT) inhibitor
Chemical Name:	2,2',2'',2'''-[[4,8-Bis(hexahydro-1(2H)-azocinyl)pyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilo]tetrakisethanol
Purity:	≥98% (HPLC)
Molecular Weight:	560.73

View Full Technical Details for 8MDP

Technical Data
Citations

Biological Activity for 8MDP

8MDP is a potent equilibrative nucleoside transporter 1 (ENT1) inhibitor (IC₅₀ = 0.43 nM). Inhibits hENT1 and hENT2 uptake of [H³]uridine in K562 cells and K15NTD cells respectively.

Compound Libraries for 8MDP

8MDP is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for 8MDP

M. Wt	560.73
Formula	C₂₈H₄₈N₈O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	29491-75-6
PubChem ID	16756415
InChi Key	KXOCTHJHIGLQKJ-UHFFFAOYSA-N
Smiles	OCCN(CCO)C2=NC1=C(N3CCCCCCC3)N=C(N(CCO)CCO)N=C1C(N4CCCCCCC4)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 8MDP

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	11.21	20

Preparing Stock Solutions for 8MDP

The following data is based on the product molecular weight 560.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	8.92 mL	44.58 mL	89.17 mL
1 mM	1.78 mL	8.92 mL	17.83 mL
2 mM	0.89 mL	4.46 mL	8.92 mL
10 mM	0.18 mL	0.89 mL	1.78 mL

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Reconstitution Calculator

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References for 8MDP

References are publications that support the biological activity of the product.

Lin Synthesis, flow cytometric evaluation, and identification of highly potent dipyrid. analogues as equilibrative nucleoside transporter 1 inhibitors. J.Med.Chem. 2007 PMID: 17636949
Lin Design, synthesis, and evaluation of 2-diethanolamino-4,8-diheptamethyleneimino-2-(N-aminoethyl-N-ethanolamino)-6-(N,N-diethanolamino)pyrimido[5,4-d]pyrimidine-fluorescein conjugate (8MDP-fluor), as a novel equilibrativ Bioconjug.Chem. 2011 PMID: 21539390