968

Name: 968
Brand: Tocris Bioscience
SKU: 5460

Tocris Bioscience, part of Bio-Techne | Catalog # 5460

COA / SDS

Allosteric inhibitor of glutaminase

Key Product Details

Description:	Allosteric inhibitor of glutaminase
Chemical Name:	5-[3-Bromo-4-(dimethylamino)phenyl]-2,3,5,6-tetrahydro-2,2-dimethylbenzo[a]phenanthridin-4(1H)-one
Purity:	≥99% (HPLC)
Molecular Weight:	475.42

View Full Technical Details for 968

Technical Data
Citations

Biological Activity for 968

968 is an allosteric inhibitor of glutaminase. Blocks Rho-GTPase-dependent transformation of fibroblasts. Suppresses breast cancer cell growth and invasive activity in vitro. Also inhibits P-493 B lymphoma cell growth and reduces tumor size of P-493 cell xenografts in mice.

Technical Data for 968

M. Wt	475.42
Formula	C₂₇H₂₇BrN₂O
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	311795-38-7
PubChem ID	3099980
InChi Key	NVFRRJQWRZFDLM-UHFFFAOYSA-N
Smiles	BrC1=CC(C(C5=C4CC(C)(C)CC5=O)NC3=C4C2=CC=CC=C2C=C3)=CC=C1N(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 968

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.51	20

Preparing Stock Solutions for 968

The following data is based on the product molecular weight 475.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	10.52 mL	52.59 mL	105.17 mL
1 mM	2.10 mL	10.52 mL	21.03 mL
2 mM	1.05 mL	5.26 mL	10.52 mL
10 mM	0.21 mL	1.05 mL	2.10 mL

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References for 968

References are publications that support the biological activity of the product.

Stalnecker Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells. Proc.Natl.Acad.Sci.U.S.A. 2015 PMID: 25548170
Lu Cancer metabolism: is glutamine sweeter than glucose? Cancer Cell 2010 PMID: 20832746
Wang Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell 2010 PMID: 20832749

968