A 1070722

Name: A 1070722
Brand: Tocris Bioscience
SKU: 4431

Tocris Bioscience, part of Bio-Techne | Catalog # 4431

Citations (5)

COA / SDS

Highly potent, selective GSK-3 inhibitor

Key Product Details

Chemical Name:	1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
Purity:	≥99%

View Full Technical Details for A 1070722

Technical Data
Citations

Biological Activity for A 1070722

A 1070722 is a potent glycogen synthase kinase-3 (GSK-3) inhibitor (K_i = 0.6 nM for GSK-3α and GSK-3β). Displays high selectivity (> 50-fold) for GSK-3 over a panel of other kinases tested, including CDK family members. Decreases phosphorylation of microtubule-associated protein Tau in vitro; protects rat primary cortical neurons against β amyloid and glutamate challenge. Brain penetrant.

Technical Data for A 1070722

Formula	C₁₇H₁₃F₃N₄O₂
Storage	Store at RT
Purity	≥99%
CAS Number	1384424-80-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A 1070722

Solubility

Soluble Soluble to 100 mM in DMSO

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References for A 1070722

References are publications that support the biological activity of the product.

Bakker et al. A-1070722, a potent, selective, and centrally active glycogen synthase kinase-3 (GSK-3) inhibitor for the treatment of psychiatric and neurodegenerative disorders. Society for Neuroscience (Abstract), 2011;:568

A 1070722

Tocris Bioscience, part of Bio-Techne | Catalog # 4431

Key Product Details

Biological Activity for A 1070722

Technical Data for A 1070722

Solubility for A 1070722

Dilution Calculator

Reconstitution Calculator

References for A 1070722

Product Documents for A 1070722

COA

Certificate of Analysis

SDS

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