A 1899

Name: A 1899
Brand: Tocris Bioscience
SKU: 6972

Tocris Bioscience, part of Bio-Techne | Catalog # 6972

Citations (4)

COA / SDS

Potent K2P3.1 (TASK-1) and K2P9.1 (TASK-3) blocker

Key Product Details

Description:	Potent K_2P3.1 (TASK-1) and K_2P9.1 (TASK-3) blocker
Chemical Name:	N-[(2,4-Difluorophenyl)methyl]-2'-[[[2-(4-methoxyphenyl)acetyl]amino]methyl][1,1'-biphenyl]-2-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	500.55

View Full Technical Details for A 1899

Technical Data
Citations

Biological Activity for A 1899

A 1899 is a potent K_2P3.1 (TASK-1) and K_2P9.1 (TASK-3) channel blocker (IC₅₀ values are 7 nM and 70 nM for human TASK-1 and TASK-3 expressed in CHO cells, respectively). Displays >12.5-fold selectivity for TASK-1 and TASK-3 over other K⁺ channels (IC₅₀ = 0.9 μM for K_2P18.1/TRESK and >2 μM for all other channels tested). Binds within open channel pore.

Compound Libraries for A 1899

A 1899 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for A 1899

M. Wt	500.55
Formula	C₃₀H₂₆F₂N₂O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	498577-46-1
PubChem ID	9827303
InChi Key	IXKPEYHRIVQTCU-UHFFFAOYSA-N
Smiles	COC1=CC=C(C=C1)CC(NCC2=C(C3=C(C(NCC4=C(C=C(C=C4)F)F)=O)C=CC=C3)C=CC=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A 1899

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	50.05	100

Preparing Stock Solutions for A 1899

The following data is based on the product molecular weight 500.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.00 mL	9.99 mL	19.98 mL
5 mM	0.40 mL	2.00 mL	4.00 mL
10 mM	0.20 mL	1.00 mL	2.00 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for A 1899

References are publications that support the biological activity of the product.

Streit A specific two-pore domain potassium channel blocker defines the structure of the TASK-1 open pore. J.Biol.Chem. 2011 PMID: 21362619