A 410099.1

Name: A 410099.1
Brand: Tocris Bioscience
SKU: 6470

Tocris Bioscience, part of Bio-Techne | Catalog # 6470

Citations (2)

COA / SDS

High affinity XIAP antagonist; active in vivo

Key Product Details

Description:	High affinity XIAP antagonist; active in vivo
Chemical Name:	N-Methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-L-prolinamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	505.09

View Full Technical Details for A 410099.1

Technical Data
Citations

Biological Activity for A 410099.1

A 410099.1 is a high affinity XIAP antagonist (K_d = 16 nM for the BIR3 domain of XIAP). Exhibits cytotoxicity in a wide range of cancer cell lines in vitro (EC₅₀ = 13 nM in MDA-MB-231 cells). Also displays antitumor activity in a mouse breast cancer xenograft model. Enhances TRAIL-induced apoptosis in chronic lymphocytic leukemia (CLL) cells.

Compound Libraries for A 410099.1

A 410099.1 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for A 410099.1

M. Wt	505.09
Formula	C₂₇H₄₀N₄O₃.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	762274-58-8
PubChem ID	131858992
InChi Key	OPCYOBWCDDJCFT-VOSOYEAFSA-N
Smiles	CN[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@@H]2CCCC3=CC=CC=C23)=O)=O)C4CCCCC4)=O)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A 410099.1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	50.51	100
	DMSO	50.51	100

Preparing Stock Solutions for A 410099.1

The following data is based on the product molecular weight 505.09.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.98 mL	9.90 mL	19.80 mL
5 mM	0.40 mL	1.98 mL	3.96 mL
10 mM	0.20 mL	0.99 mL	1.98 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for A 410099.1

References are publications that support the biological activity of the product.

Loeder A novel paradigm to trigger apoptosis in chronic lymphocytic leukemia. Cancer Res. 2009 PMID: 19920200
Oost Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer. J.Med.Chem. 2004 PMID: 15317454