A 412997 dihydrochloride

Name: A 412997 dihydrochloride
Brand: Tocris Bioscience
SKU: 4552

Tocris Bioscience, part of Bio-Techne | Catalog # 4552

Citations (1)

COA / SDS

Selective D4 agonist

Key Product Details

Chemical Name:	N-(3-Methylphenyl)-4-(2-pyridinyl)-1-piperidineacetamide
Purity:	≥98%

View Full Technical Details for A 412997 dihydrochloride

Technical Data
Citations

Biological Activity for A 412997 dihydrochloride

A 412997 dihydrochloride is a selective agonist for the dopamine D₄ receptor (K_i values are 7.9 and 12.1 nM for human D₄ and rat D₄ receptors). Displays no affinity (<1000 nM) for other dopamine receptors. Shows efficacy in rat models of ADHD and short-term memory.

Technical Data for A 412997 dihydrochloride

Formula	C₁₉H₂₃N₃O.2HCl
Storage	Desiccate at RT
Purity	≥98%
CAS Number	1347744-96-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A 412997 dihydrochloride

Solubility

Soluble Soluble to 100 mM in water and to 50 mM in DMSO

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References for A 412997 dihydrochloride

References are publications that support the biological activity of the product.

Moreland et al. A-412997 is a selective DA D₄ receptor agonist in rats. Pharmacol.Biochem.Behav., 2005;82:140 PMID: 16153699
Browman et al. A-412997, a selective DA D₄ agonist, improves cognitive performance in rats. Pharmacol.Biochem.Behav., 2005;82:148 PMID: 16154186
Patel et al. Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable DA D₄ agonist for the treatment of erectile dysfunction. J.Med.Chem., 2006;49:7450 PMID: 17149874

A 412997 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4552

Key Product Details

Biological Activity for A 412997 dihydrochloride

Technical Data for A 412997 dihydrochloride

Solubility for A 412997 dihydrochloride

Dilution Calculator

Reconstitution Calculator

References for A 412997 dihydrochloride

Product Documents for A 412997 dihydrochloride

COA

Certificate of Analysis

SDS

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