A-71623

Tocris Bioscience, part of Bio-Techne | Catalog # 2411

COA / SDS

Potent and selective CCK1 agonist; suppresses feeding

Key Product Details

Description:	Potent and selective CCK₁ agonist; suppresses feeding
Purity:	≥95% (HPLC)
Molecular Weight:	840.97

View Full Technical Details for A-71623

Technical Data
Citations

Biological Activity for A-71623

A-71623 is a potent CCK₁ agonist (IC₅₀ = 3.7 nM) with 1200-fold selectivity over the CCK₂ receptor. Suppresses food intake following central or peripheral administration.

Technical Data for A-71623

M. Wt	840.97
Formula	C₄₄H₅₆N₈O₉
Single Letter Sequence	WKDF (Modifications: Trp-1 = Boc-Trp, Lys-2 = Lys(Tac), Phe-4 = N-methyl-Phe & C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	130408-77-4
PubChem ID	121964
InChi Key	KNHCBYMGWWTGSO-ZYADHFCISA-N
Smiles	O=C(N[C@H]([C@](N[C@@H](CC(O)=O)C(N(C)[C@@H](CC3=CC=CC=C3)C(N)=O)=O)=O)CCCCNC(NC4=CC=CC=C4C)=O)[C@@H](NC(OC(C)(C)C)=O)CC1=CNC2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A-71623

Solubility

Soluble to 1mg/ml in 20mM PBS buffer

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for A-71623

References are publications that support the biological activity of the product.

DeNinno Development of CCK-tetrapeptide analogues as potent and selective CCK-A receptor agonists. J.Med.Chem.
Lin Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors. Mol.Pharmacol.
Asin A-71623, a selective CCK-A receptor agonist, suppresses food intake in the mouse, dog, and monkey. Pharmacol.Biochem.Behav. 1992 PMID: 1513850