A 77636 hydrochloride

Name: A 77636 hydrochloride
Brand: Tocris Bioscience
SKU: 1701

Tocris Bioscience, part of Bio-Techne | Catalog # 1701

Citations (8)

COA / SDS

Potent and selective D1-like agonist; orally active

Key Product Details

Description:	Potent and selective D₁-like agonist; orally active
Chemical Name:	(1R-cis)-1-(Aminomethyl)-3,4-dihydro-3-tricyclo[3.3.1.13,7]dec-1-yl-[1H]-2-benzopyran-5,6-diol hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	365.9

View Full Technical Details for A 77636 hydrochloride

Technical Data
Citations

Biological Activity for A 77636 hydrochloride

A 77636 hydrochloride is a potent and selective dopamine D₁-like receptor agonist (pEC₅₀ values are 8.97 and < 5 for D₁-like and D₂-like receptors respectively). Displays anti-Parkinsonian activity following oral administration in vivo. Exhibits 11-fold cell type bias over dopamine in a functional assay in U2 cells.

Technical Data for A 77636 hydrochloride

M. Wt	365.9
Formula	C₂₀H₂₇NO₃.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	145307-34-2
PubChem ID	9811493
InChi Key	RSJAXPUYVJKAAA-JPGJPTAESA-N
Smiles	NC[C@@H]2O[C@H]([C@]35CC(CC(C5)C4)CC4C3)CC1=C(O)C(O)=CC=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A 77636 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	36.59	100

Preparing Stock Solutions for A 77636 hydrochloride

The following data is based on the product molecular weight 365.9.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.73 mL	13.66 mL	27.33 mL
5 mM	0.55 mL	2.73 mL	5.47 mL
10 mM	0.27 mL	1.37 mL	2.73 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

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References for A 77636 hydrochloride

References are publications that support the biological activity of the product.

Kebabian A-77636: a potent and selective DA D₁ receptor agonist with antiparkinsonian activity in marmosets. Eur.J.Pharmacol. 1992 PMID: 1362704
Lewis Homologous desensitization of the D_1A DA receptor: efficacy in causing desensitization dissociates from both receptor occupancy and functional potency. J.Pharmacol.Exp.Ther. 1998 PMID: 9655879
Acquas The potent and selective DA D₁ receptor agonist A-77636 increases cortical and hippocampal acetylcholine release in the rat. Eur.J.Pharmacol. 1994 PMID: 7957630