A 803467

Name: A 803467
Brand: Tocris Bioscience
SKU: 2976

Tocris Bioscience, part of Bio-Techne | Catalog # 2976

Citations (35)

COA / SDS

Selective NaV1.8 channel blocker

Key Product Details

Description:	Selective Na_V1.8 channel blocker
Chemical Name:	5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	357.79

View Full Technical Details for A 803467

Technical Data
Citations

Biological Activity for A 803467

A 803467 is a selective blocker of Na_V1.8 channels (IC₅₀ values are 8, 2450, 6740, 7340 and 7380 nM for hNa_V1.8, hNa_V1.3, hNa_V1.7, hNa_V1.5 and hNa_V1.2 channels respectively). Shows no significant activity against TRPV1, P2X_2/3, Ca_V2.2 and KCNQ2/3 channels. Antinociceptive; potently attenuates mechanical allodynia in two models of neuropathic pain following i.p. administration.

Compound Libraries for A 803467

A 803467 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for A 803467

M. Wt	357.79
Formula	C₁₉H₁₆ClNO₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	944261-79-4
PubChem ID	16038374
InChi Key	VHKBTPQDHDSBSP-UHFFFAOYSA-N
Smiles	ClC(C=C2)=CC=C2C1=CC=C(C(NC3=CC(OC)=CC(OC)=C3)=O)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A 803467

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	35.78	100
	ethanol	8.94	25

Preparing Stock Solutions for A 803467

The following data is based on the product molecular weight 357.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.79 mL	13.97 mL	27.95 mL
5 mM	0.56 mL	2.79 mL	5.59 mL
10 mM	0.28 mL	1.40 mL	2.79 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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References for A 803467

References are publications that support the biological activity of the product.

Jarvis A-803467, a potent and selective Na_V1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Proc.Natl.Acad.Sci. 2007 PMID: 17483457
McGaraughty A selective NaV1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats. J.Pharmacol.Exp.Ther. 2008 PMID: 18089840
Kort Discovery and biological evaluation of 5-Aryl-2-furfuramides, potent and selective blockers of the Na_v1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain. J.Med.Chem. 2008 PMID: 18176998
Rush and Cummins Painful research: identification of a small-molecule inhibitor that selectively targets Na_V1.8 sodium channels. Mol.Interv. 2007 PMID: 17827438