A 887826

Name: A 887826
Brand: Tocris Bioscience
SKU: 4249

Tocris Bioscience, part of Bio-Techne | Catalog # 4249

Citations (3)

COA / SDS

Potent voltage-dependent NaV1.8 channel blocker

Key Product Details

Description:	Potent voltage-dependent Na_V1.8 channel blocker
Chemical Name:	5-(4-Butoxy-3-chlorophenyl)-N-[[2-(4-morpholinyl)-3-pyridinyl]methyl-3-pyridine carboxamide
Purity:	≥97% (HPLC)
Molecular Weight:	480.99

View Full Technical Details for A 887826

Technical Data
Citations

Biological Activity for A 887826

A 887826 is a potent voltage-dependent Na_V1.8 channel blocker (IC₅₀ = 11 nM in recombinant human Na_V1.8 channels). Reduces tactile allodynia in neuropathic rat models. 3- and 28-fold more potent at Na_V1.8 channels compared to Na_V1.2 and Na_V1.7 channels respectively.

Compound Libraries for A 887826

A 887826 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for A 887826

M. Wt	480.99
Formula	C₂₆H₂₉ClN₄O₃
Storage	Store at RT
Purity	≥97% (HPLC)
CAS Number	1266212-81-0
PubChem ID	46919335
InChi Key	JPJGFWKHSMUKFO-UHFFFAOYSA-N
Smiles	ClC1=C(OCCCC)C=CC(C2=CN=CC(C(NCC3=CC=CN=C3N4CCOCC4)=O)=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A 887826

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	24.05	50

Preparing Stock Solutions for A 887826

The following data is based on the product molecular weight 480.99.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.16 mL	20.79 mL	41.58 mL
2.5 mM	0.83 mL	4.16 mL	8.32 mL
5 mM	0.42 mL	2.08 mL	4.16 mL
25 mM	0.08 mL	0.42 mL	0.83 mL

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References for A 887826

References are publications that support the biological activity of the product.

Zhang A-887826 is a structurally novel, potent and voltage-dependent Na_V1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats. Neuropharmacology 2010 PMID: 20566409