A 943931 dihydrochloride

Name: A 943931 dihydrochloride
Brand: Tocris Bioscience
SKU: 3753

Tocris Bioscience, part of Bio-Techne | Catalog # 3753

Citations (2)

COA / SDS

Potent and selective H4 antagonist

Discontinued Product

3753 has been discontinued. View all Histamine H4 Receptor Antagonists products.

Key Product Details

Description:	Potent and selective H₄ antagonist
Chemical Name:	4-((3R)-3-amino-pyrrolidin-1-yl)-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidin-2-ylamine
Purity:	≥98% (HPLC)
Molecular Weight:	368.31

View Full Technical Details for A 943931 dihydrochloride

Technical Data
Citations

Biological Activity for A 943931 dihydrochloride

A 943931 dihydrochloride is a potent and selective histamine H₄ receptor antagonist (pK_i values are 7.15 and 8.12 at human and rat receptors respectively). Blocks inflammation in a peritonitis mouse model and displays efficacy in inflammatory pain and neuropathic pain models.

Technical Data for A 943931 dihydrochloride

M. Wt	368.31
Formula	C₁₇H₂₁N₅.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1227675-50-4
PubChem ID	56972240
InChi Key	ISYUFRNZHUOGLA-CURYUGHLSA-N
Smiles	NC1=NC(N4C[C@H](N)CC4)=C2C(C(C=CC=C3)=C3CCC2)=N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for A 943931 dihydrochloride

References are publications that support the biological activity of the product.

Leurs Molecular and biochemical pharmacology of the histamine H₄ receptor. Br.J.Pharmacol. 2009 PMID: 19413568
Aldi Histamine H4-Receptors Inhibit Mast Cell Renin Release in Ischemia/Reperfusion via PKC{epsilon}-Dependent Aldehyde Dehydrogenase Type-2 Activation. J.Pharmacol.Exp.Ther. 2014 PMID: 24696042
Cowart Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H₄ receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models. J.Med.Chem. 2008 PMID: 18817367

A 943931 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 3753

Key Product Details

Biological Activity for A 943931 dihydrochloride

Technical Data for A 943931 dihydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for A 943931 dihydrochloride

Product Documents for A 943931 dihydrochloride

COA

Certificate of Analysis

SDS

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