α-helical CRF 9-41

Name: α-helical CRF 9-41
Brand: Tocris Bioscience
SKU: 1184
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1184

COA / SDS

CRF antagonist

Discontinued Product

1184 has been discontinued. View all Non-selective CRF Receptor Antagonists products.

Key Product Details

Description:	CRF antagonist
Alternative Names:	α-helical-Corticotropin-Releasing Factor 9-41
Purity:	≥95% (HPLC)
Molecular Weight:	3827

View Full Technical Details for α-helical CRF 9-41

Technical Data
Citations

Biological Activity for α-helical CRF 9-41

α-helical CRF 9-41 is a corticotropin-releasing factor receptor antagonist (K_i values are 17, 5 and 0.97 at human CRF₁, rat CRF_2α and mouse CRF_2β receptors respectively).

Licensing Information

Sold with the permission of the SALK Institute

Technical Data for α-helical CRF 9-41

M. Wt	3827
Formula	C₁₆₆H₂₇₄N₄₆O₅₃S₂
Single Letter Sequence	DLTFHLLREMLEMAKAEQEAEQAALNRLLLEEA (Modifications: Ala-33 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	90880-23-2
PubChem ID	44593730
InChi Key	PNGVJHODDQMQKT-GVKLFNHCSA-N
Smiles	[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for α-helical CRF 9-41

References are publications that support the biological activity of the product.

Perrin and Vale Corticotropin releasing factor receptors and their ligand family. Ann.N.Y.Acad.Sci. 1999 PMID: 10816663
Swerdlow Potentiation of acoustic startle by corticotropin-releasing factor (CRF) and by fear are both reversed by α-helical CRF (9-41). Neuropsychopharmacology 1989 PMID: 2610824
Kask Alpha-helical(9-41) revents anxiogenic-like effect of NPY Y₁ receptor antagonist BIBP3226. NeuroReport 1997 PMID: 9427342