α-Synuclein Degrader 2b

Name: α-Synuclein Degrader 2b
Brand: Tocris Bioscience
SKU: 8040

Tocris Bioscience, part of Bio-Techne | Catalog # 8040

COA / SDS

α-synuclein Degrader (PROTAC®)

Key Product Details

Description:	α-synuclein Degrader (PROTAC^®)
Chemical Name:	2-[[3-[5-(1,3-Benzodioxol-5-yl)-1H-pyrazol-3-yl]phenyl]amino]-N-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	767.8

View Full Technical Details for α-Synuclein Degrader 2b

Technical Data
Citations

Biological Activity for α-Synuclein Degrader 2b

α-Synuclein Degrader 2b is a selective α-synuclein Degrader (PROTAC^®) (DC₅₀ = 7.5 μM; D_max = 89%). Comprises the probe molecule sery308, joined by a linker to a pomalidomide E3 ligase ligand. Activates both proteasomal and lysosomal degradation pathways. Protects SH-SY5Y cells from α-synuclein-induced cytotoxicity. Cell permeable.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for α-Synuclein Degrader 2b

M. Wt	767.8
Formula	C₃₉H₄₁N₇O₁₀
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2781922-42-5
InChi Key	IYFKRANQUJUTKF-UHFFFAOYSA-N
Smiles	O=C(CNC1=CC=CC(C2=NNC(C3=CC4=C(OCO4)C=C3)=C2)=C1)NCCOCCOCCOCCNC5=CC=CC(C(N6C7C(NC(CC7)=O)=O)=O)=C5C6=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for α-Synuclein Degrader 2b

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	76.78	100

Preparing Stock Solutions for α-Synuclein Degrader 2b

The following data is based on the product molecular weight 767.8.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.30 mL	6.51 mL	13.02 mL
5 mM	0.26 mL	1.30 mL	2.60 mL
10 mM	0.13 mL	0.65 mL	1.30 mL
50 mM	0.03 mL	0.13 mL	0.26 mL

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References for α-Synuclein Degrader 2b

References are publications that support the biological activity of the product.

Tong Discovery of small-molecule degraders for alpha-synuclein aggregates. J.Med.Chem. 2023 PMID: 37267712