AAQ chloride

Name: AAQ chloride
Brand: Tocris Bioscience
SKU: 5462

Tocris Bioscience, part of Bio-Techne | Catalog # 5462

COA / SDS

Photoswitchable Kv channel blocker

Key Product Details

Description:	Photoswitchable K_v channel blocker
Chemical Name:	N,N,N-Triethyl-2-oxo-2-[[4-[2-[4-[(1-oxo-2-propen-1-yl)amino]phenyl]diazenyl]phenylamino]ethanaminium chloride
Purity:	≥98% (HPLC)
Molecular Weight:	443.97

View Full Technical Details for AAQ chloride

Technical Data
Citations

Biological Activity for AAQ chloride

AAQ chloride is a photoswitchable K_v channel blocker (IC₅₀ values are 2 and 64 μM at 500 nm and 380 nm respectively). Switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. Exhibits minimal activity at Na_v1.2 and L-type Ca²⁺ channels. Stimulates action potential firing of hippocampal neurons in vitro at 500 nm and restores visual responsiveness in blind mice at 380 nm.

Licensing Information

Sold under license from Photoswitch Biosciences, Inc.

Technical Data for AAQ chloride

M. Wt	443.97
Formula	C₂₃H₃₀ClN₅O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
PubChem ID	91826090
InChi Key	CTVKLIGDHHKPIB-UHFFFAOYSA-N
Smiles	O=C(C=C)NC(C=C2)=CC=C2/N=N/C1=CC=C(NC(C[N+](CC)(CC)CC)=O)C=C1.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AAQ chloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	8.88	20

Preparing Stock Solutions for AAQ chloride

The following data is based on the product molecular weight 443.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.26 mL	56.31 mL	112.62 mL
1 mM	2.25 mL	11.26 mL	22.52 mL
2 mM	1.13 mL	5.63 mL	11.26 mL
10 mM	0.23 mL	1.13 mL	2.25 mL

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References for AAQ chloride

References are publications that support the biological activity of the product.

Polosukhina Photochemical restoration of visual responses in blind mice. Neuron 2012 PMID: 22841312
Banghart Photochromic blockers of voltage-gated potassium channels. Angew.Chem.Int.Ed. 2009 PMID: 19882609
Fortin Photochemical control of endogenous ion channels and cellular excitability. Nat.Methods 2008 PMID: 18311146