Abiraterone acetate

Name: Abiraterone acetate
Brand: Tocris Bioscience
SKU: 6520

Tocris Bioscience, part of Bio-Techne | Catalog # 6520

COA / SDS

Potent CYP17A1 inhibitor

Key Product Details

Description:	Potent CYP17A1 inhibitor
Chemical Name:	(3β)-17-(3-Pyridinyl)androsta-5,16-dien-3-yl acetate
Purity:	≥98% (HPLC)
Molecular Weight:	391.55

View Full Technical Details for Abiraterone acetate

Technical Data
Citations

Biological Activity for Abiraterone acetate

Abiraterone acetate is a potent CYP17A1 inhibitor (IC₅₀ values are 17 nM and 18 nM for 17,20-lyase activity and 17α-hydroxylase activity, respectively). Inhibits intratumor androgen synthesis in prostate cancer.

Compound Libraries for Abiraterone acetate

Abiraterone acetate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Abiraterone acetate

M. Wt	391.55
Formula	C₂₆H₃₃NO₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	154229-18-2
PubChem ID	9821849
InChi Key	UVIQSJCZCSLXRZ-UBUQANBQSA-N
Smiles	[H][C@@]12CC=C([C@]1(CC[C@]3([C@]2(CC=C4C[C@@H](OC(C)=O)CC[C@]34C)[H])[H])C)C5=CN=CC=C5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Abiraterone acetate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	7.83	20
	ethanol	39.16	100

Preparing Stock Solutions for Abiraterone acetate

The following data is based on the product molecular weight 391.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.55 mL	12.77 mL	25.54 mL
5 mM	0.51 mL	2.55 mL	5.11 mL
10 mM	0.26 mL	1.28 mL	2.55 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

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Reconstitution Calculator

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References for Abiraterone acetate

References are publications that support the biological activity of the product.

Barrie Pharmacology of novel steroidal inhibitors of cytochrome P450(17) alpha (17 alpha-hydroxylase/C17-20 lyase). J.Steroid Biochem.Mol.Biol. 1994 PMID: 7918112
Potter Novel steroidal inhibitors of human cytochrome P450_17α (l7α-Hydroxylase-C_l7,20-lyase): potential agents for the treatment of prostatic cancer. J.Med.Chem. 1995 PMID: 7608911

Product Documents for Abiraterone acetate

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Abiraterone acetate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov