ABT 639

Name: ABT 639
Brand: Tocris Bioscience
SKU: 6770

Tocris Bioscience, part of Bio-Techne | Catalog # 6770

Citations (1)

COA / SDS

CaV3.2 and CaV3.1 channel blocker; orally bioavailable

Key Product Details

Description:	Ca_V3.2 and Ca_V3.1 channel blocker; orally bioavailable
Chemical Name:	4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]benzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	455.91

View Full Technical Details for ABT 639

Technical Data
Citations

Biological Activity for ABT 639

ABT 639 is a Ca_V3.2 channel blocker (IC₅₀ = 2.3 μM). Also blocks low voltage-activated (Ca_V3.1) currents in native rat DRG neurons (IC₅₀ = 7.6 μM). Exhibits little or no activity at other ion channels and receptors. Displays antinociceptive effects in a mechanical hyperalgesia model in vivo. Orally bioavailable.

Compound Libraries for ABT 639

ABT 639 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ABT 639

M. Wt	455.91
Formula	C₂₀H₂₀ClF₂N₃O₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1235560-28-7
PubChem ID	46851313
InChi Key	AGPIHNZOZNKRGT-CYBMUJFWSA-N
Smiles	[H][C@]12CCCN1CCN(C(C3=CC(S(=O)(NC4=C(C=CC=C4)F)=O)=C(C=C3Cl)F)=O)C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ABT 639

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.12	20

Preparing Stock Solutions for ABT 639

The following data is based on the product molecular weight 455.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	10.97 mL	54.84 mL	109.67 mL
1 mM	2.19 mL	10.97 mL	21.93 mL
2 mM	1.10 mL	5.48 mL	10.97 mL
10 mM	0.22 mL	1.10 mL	2.19 mL

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References for ABT 639

References are publications that support the biological activity of the product.

Zhang Optimization of ADME properties for sulfonamides leading to the discovery of a T-type calcium channel blocker, ABT-639. ACS Med.Chem.Lett. 2015 PMID: 26101566