ABT 737

Name: ABT 737
Brand: Tocris Bioscience
SKU: 6835

Tocris Bioscience, part of Bio-Techne | Catalog # 6835

Citations (5)

COA / SDS

Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines

Key Product Details

Description:	Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines
Chemical Name:	4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	813.43

View Full Technical Details for ABT 737

Technical Data
Citations

Biological Activity for ABT 737

ABT 737 is a high affinity Bcl-2 family inhibitor (K_i ≤ 1nM for Bcl-X_L, Bcl-2 and Bcl-w). BH3 mimetic; triggers Bax/Bak-mediated apoptosis. Exhibits cytotoxicity in lymphoma cell lines overexpressing bcl-2 (EC₅₀ < 1 μM) and multiple myeloma cells (IC₅₀ = 5-15 μM). Induces apoptosis in patient-derived CLL cells. Promotes regression of SCLC tumors in a mouse xenograft model. Synergizes with certain other anticancer agents.

Technical Data for ABT 737

M. Wt	813.43
Formula	_C42H₄₅ClN₆O₅S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	852808-04-9
PubChem ID	11228183
InChi Key	HPLNQCPCUACXLM-PGUFJCEWSA-N
Smiles	CN(CC[C@@H](NC1=C([N+]([O-])=O)C=C(S(=O)(NC(C2=CC=C(N3CCN(CC3)CC4=C(C5=CC=C(C=C5)Cl)C=CC=C4)C=C2)=O)=O)C=C1)CSC6=CC=CC=C6)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ABT 737

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	81.34	100

Preparing Stock Solutions for ABT 737

The following data is based on the product molecular weight 813.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.23 mL	6.15 mL	12.29 mL
5 mM	0.25 mL	1.23 mL	2.46 mL
10 mM	0.12 mL	0.61 mL	1.23 mL
50 mM	0.02 mL	0.12 mL	0.25 mL

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References for ABT 737

References are publications that support the biological activity of the product.

van Delft, MF The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell. 2006 PMID: 17097561
Kline ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells. Leukemia 2007 PMID: 17460700
Oltersdorf An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 2005 PMID: 15902208