AC 264613

Name: AC 264613
Brand: Tocris Bioscience
SKU: 3370

Tocris Bioscience, part of Bio-Techne | Catalog # 3370

Citations (5)

COA / SDS

PAR2 receptor agonist

Key Product Details

Chemical Name:	(±)-(3R,4S)-2-Oxo-4-phenyl-3-pyrollidinecarboxylic acid 2-[1-(3-bromophenyl)ethylidene]hydrazide
Purity:	≥98%
Molecular Weight:	400.27 kDa

View Full Technical Details for AC 264613

Technical Data
Citations

Biological Activity for AC 264613

AC 264613 is a potent and selective protease-activated receptor 2 (PAR₂) agonist (pEC₅₀ = 7.5). Displays no activity at other PAR subtypes and exhibits no significant activity at over 30 other receptors implicated in nociception and inflammation. Stimulates PI hydrolysis, Ca²⁺ mobilization and cellular proliferation in vitro (pEC₅₀ values are 6.9, 7.0 and 7.5 respectively).

Technical Data for AC 264613

M. Wt	400.27 kDa
Formula	C₁₉H₁₈BrN₃O₂
Storage	Store at -20°C
Purity	≥98%
CAS Number	1051487-82-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AC 264613

Solubility

Soluble Soluble to 100 mM in DMSO

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References for AC 264613

References are publications that support the biological activity of the product.

Seitzberg et al. Discovery of potent and selective small-molecule PAR-2 agonists. J.Med.Chem., 2008;51:5490 PMID: 18720984
Gardell et al. Identification and characterization of novel small-molecule protease-activated receptor 2 agonists. J.Pharmacol.Exp.Ther., 2008;327:799 PMID: 18768780