AC 5216

Name: AC 5216
Brand: Tocris Bioscience
SKU: 5281

Tocris Bioscience, part of Bio-Techne | Catalog # 5281

Citations (1)

COA / SDS

Selective TSPO ligand

Key Product Details

Chemical Name:	N-Ethyl-7,8-dihydro-7-methyl-8-oxo-2-phenyl-N-(phenylmethyl)-9H-purine-9-acetamide
Purity:	≥98%

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Technical Data
Citations

Biological Activity for AC 5216

AC 5216 is a ligand of translocator protein (TSPO, peripheral benzodiazepine receptor). Exhibits high affinity for TSPO in rat whole brain (K_i = 0.297 nM), and high potency against human and rat glial TSPO (IC₅₀ values are 2.73 and 3.04 nM respectively). Displays no noticeable binding to a number of other receptors, transporters or ion channels. Also displays anxiolytic and antidepressant effects in rodent models, without inducing benzodiazepine-like adverse effects.

Technical Data for AC 5216

Formula	C₂₃H₂₃N₅O₂
Storage	Store at +4°C
Purity	≥98%
CAS Number	226954-04-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AC 5216

Solubility

Soluble Soluble to 100 mM in DMSO

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References for AC 5216

References are publications that support the biological activity of the product.

Kita et al. Antianxiety and antidepressant-like effects of AC-5216, a novel mitochondrial benzodiazepine receptor ligand. Br.J.Pharmacol., 2004;142:1059 PMID: 15249420
Qiu et al. Repeated administration of AC-5216, a ligand for the 18kDa translocator protein, improves behavioral deficits in a mouse model of post-traumatic stress disorder. Prog.Neuropsychopharmacol.Biol.Psychiatry, 2013;45:40 PMID: 23624119

AC 5216

Tocris Bioscience, part of Bio-Techne | Catalog # 5281

Key Product Details

Biological Activity for AC 5216

Technical Data for AC 5216

Solubility for AC 5216

Dilution Calculator

Reconstitution Calculator

References for AC 5216

Product Documents for AC 5216

COA

Certificate of Analysis

SDS

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