Ac2-26

Name: Ac2-26
Brand: Tocris Bioscience
SKU: 1845

Tocris Bioscience, part of Bio-Techne | Catalog # 1845

Citations (43)

COA / SDS

Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation

Key Product Details

Purity:	≥95%
Molecular Weight:	3089.46 kDa

View Full Technical Details for Ac2-26

Technical Data
Citations

Biological Activity for Ac2-26

Ac2-26 is an annexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Ac2-26 reduces neutrophil adhesion and emigration, promotes detachment of neutrophils from activated mesenteric endothelium and accelerates epithelial wound repair after induced colonic injury in mice in vivo. Anti-inflammatory. Ac2-26 inhibits the proliferation of human larynx epidermoid carcinoma Hep-2 cells in vitro. Ac2-26 decreases proliferation and increases mobility of cervical cancer cells.

Negative control also available.

Technical Data for Ac2-26

M. Wt	3089.46 kDa
Formula	C₁₄₁H₂₁₀N₃₂O₄₄S
Storage	Store at -20°C
Purity	≥95%
CAS Number	151988-33-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ac2-26

Solubility

Soluble Soluble to 1 mg/ml in PBS

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References for Ac2-26

References are publications that support the biological activity of the product.

Belvedere, Raffaell, Bizzarro, Valentin, Popolo, Ada, Dal Piaz, Fabrizio, Vasaturo, Michele, Picardi, Paola, Parente, Luca, Petrella, Antonell Role of intracellular and extracellular annexin A1 in migration and invasion of human pancreatic carcinoma cells. BMC Cancer, 2014;14(0):961. 2014 PMID: 25510623
Tibrewal S, Ivanir Y, Sarkar J, Nayeb-Hashemi N, Bouchard C, Kim E, Jain S Hyperosmolar stress induces neutrophil extracellular trap formation: implications for dry eye disease. Invest Ophthalmol Vis Sci, 2014;55(12):7961-9. 2014 PMID: 25406284
Vago J, Tavares L, Garcia C, Lima K, Perucci L, Vieira E, Nogueira C, Soriani F, Martins J, Silva P, Gomes K, Pinho V, Bruscoli S, Riccardi C, Beaulieu E, Morand E, Teixeira M, Sousa L The role and effects of glucocorticoid-induced leucine zipper in the context of inflammation resolution. J Immunol, 2015;194(10):4940-50. 2015 PMID: 25876761
Leoni, Giovanna, Neumann, Philipp-, Kamaly, Nazila, Quiros, Miguel, Nishio, Hikaru, Jones, Hefin R, Sumagin, Ronen, Hilgarth, Roland S, Alam, Ashfaqul, Fredman, Gabriell, Argyris, Ioannis, Rijcken, Emile, Kusters, Dennis, Reutelingsperger, Chris, Perretti, Mauro, Parkos, Charles, Farokhzad, Omid C, Neish, Andrew S, Nusrat, Asma Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J Clin Invest, 2015;125(3):1215-27. 2015 PMID: 25664854
Lim et al. Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc.Natl.Acad.Sci.U.S.A., 1998;95:14535 PMID: 9826735
Perretti et al. Lipocortin-1 fragments inhibit neutrophil accumulation and neutrophil-dependent edema in the mouse. A qualitative comparison with an anti-CD11b monoclonal antibody. J.Immunol., 1993;151:4306 PMID: 8409403
Perretti and Gavins Annexin 1: an endogenous anti-inflammatory protein. News Physiol.Sci., 2003;18:60 PMID: 12644621