Adapalene

Name: Adapalene
Brand: Tocris Bioscience
SKU: 2852

Tocris Bioscience, part of Bio-Techne | Catalog # 2852

Citations (10)

COA / SDS

RARβ and RARγ agonist

Key Product Details

Description:	RARβ and RARγ agonist
Alternative Names:	CD 271,Differin
Chemical Name:	6-(4-Methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	412.52

View Full Technical Details for Adapalene

Technical Data
Citations

Biological Activity for Adapalene

Adapalene is a retinoic acid analog that is a RARβ and RARγ agonist (AC₅₀ values are 2.2, 9.3, 22 and > 1000 nM for RARβ, RARγ, RARα and RXRα receptors respectively). Inhibits proliferation and induces apoptosis in colorectal cancer cell in vitro. Displays comedolytic activity.

Compound Libraries for Adapalene

Adapalene is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Adapalene

M. Wt	412.52
Formula	C₂₈H₂₈O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	106685-40-9
PubChem ID	60164
InChi Key	LZCDAPDGXCYOEH-UHFFFAOYSA-N
Smiles	COC1=CC=C(C3=CC=C(C=C(C(O)=O)C=C4)C4=C3)C=C1C25CC(C6)CC(CC6C5)C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Adapalene

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	10.31	25

Preparing Stock Solutions for Adapalene

The following data is based on the product molecular weight 412.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	9.70 mL	48.48 mL	96.96 mL
1.25 mM	1.94 mL	9.70 mL	19.39 mL
2.5 mM	0.97 mL	4.85 mL	9.70 mL
12.5 mM	0.19 mL	0.97 mL	1.94 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Adapalene

References are publications that support the biological activity of the product.

Millikan Adapalene: an update on newer comparative studies between the various retinoids. Int.J.Dermatol. 2000 PMID: 11095202
Ocker The synthetic retinoid adap. inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro. Int.J.Cancer 2003 PMID: 14506747
Shroot Pharmacology and chemistry of adap. J.Am.Acad.Dermatol. 1997 PMID: 9204085