AdipoRon hydrochloride

Name: AdipoRon hydrochloride
Brand: Tocris Bioscience
SKU: 5096

Tocris Bioscience, part of Bio-Techne | Catalog # 5096

Citations (3)

COA / SDS

Orally active AdipoR1 and AdipoR2 agonist; antidiabetic

Key Product Details

Description:	Orally active AdipoR1 and AdipoR2 agonist; antidiabetic
Chemical Name:	2-(4-Benzyoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	464.98

View Full Technical Details for AdipoRon hydrochloride

Technical Data
Citations

Biological Activity for AdipoRon hydrochloride

AdipoRon hydrochloride is an agonist of adiponectin receptors AdipoR1 and AdipoR2 (K_d values are 1.8 and 3.1 μM respectively). Activates AMPK and PPARα signaling; ameliorates insulin resistance, dyslipidemia and glucose intolerance in db/db mice. Orally active antidiabetic agent.

Compound Libraries for AdipoRon hydrochloride

AdipoRon hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AdipoRon hydrochloride

M. Wt	464.98
Formula	C₂₇H₂₈N₂O₃.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1781835-20-8
PubChem ID	78243714
InChi Key	TZVJQEGKRLDTHQ-UHFFFAOYSA-N
Smiles	O=C(C2=CC=C(OCC(NC3CCN(CC4=CC=CC=C4)CC3)=O)C=C2)C1=CC=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AdipoRon hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	46.5	100
	ethanol	4.65	10

Preparing Stock Solutions for AdipoRon hydrochloride

The following data is based on the product molecular weight 464.98.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.15 mL	10.75 mL	21.51 mL
5 mM	0.43 mL	2.15 mL	4.30 mL
10 mM	0.22 mL	1.08 mL	2.15 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

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References for AdipoRon hydrochloride

References are publications that support the biological activity of the product.

Okada-Iwabu A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature 2013 PMID: 24172895