ADU-S100 disodium salt

Name: ADU-S100 disodium salt
Brand: Tocris Bioscience
SKU: 7706

Tocris Bioscience, part of Bio-Techne | Catalog # 7706

COA / SDS

STING agonist

Key Product Details

Description:	STING agonist
Chemical Name:	[P(R)]-5'-O-[(R)-Hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-adenosine cyclic nucleotide disodium
Purity:	≥95% (HPLC)
Molecular Weight:	734.5

View Full Technical Details for ADU-S100 disodium salt

Technical Data
Citations

Biological Activity for ADU-S100 disodium salt

ADU-S100 disodium salt is a STING agonist. It induces CD8+ T-cell mediated antitumor immunity in a rat esophageal adenocarcinoma model. In mouse tumor models, the compound induces tumor regression and a potent antitumor immune response. ADU-S100 disodium salt induces phosphorylation of TBK1 and IRF3 in murine bone marrow macrophages.

Technical Data for ADU-S100 disodium salt

M. Wt	734.5
Formula	C₂₀H₂₂N₁₀Na₂O₁₀P₂S₂
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	1638750-95-4
PubChem ID	135390762
InChi Key	GDWOOOCBNOMMTL-ITQXCAEYSA-L
Smiles	O[C@H]1[C@]2([H])[C@H](N3C4=NC=NC(N)=C4N=C3)O[C@]1([H])CO[P@@]([S-])(O[C@]5([H])[C@@](O[C@@H](N6C7=NC=NC(N)=C7N=C6)[C@@H]5O)([H])CO[P@@]([S-])(O2)=O)=O.[Na+].[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ADU-S100 disodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	3.67	5

Preparing Stock Solutions for ADU-S100 disodium salt

The following data is based on the product molecular weight 734.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	27.23 mL	136.15 mL	272.29 mL
0.25 mM	5.45 mL	27.23 mL	54.46 mL
0.5 mM	2.72 mL	13.61 mL	27.23 mL
2.5 mM	0.54 mL	2.72 mL	5.45 mL

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References for ADU-S100 disodium salt

References are publications that support the biological activity of the product.

Zaidi Intratumoral immunotherapy with STING agonist, ADU-S100, induces CD8+ T-cell mediated anti-tumor immunity in an esophageal adenocarcinoma model. Oncotarget 2021 PMID: 33659041
Corrales Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep. 2015 PMID: 25959818