AEG 3482

Name: AEG 3482
Brand: Tocris Bioscience
SKU: 2651
Rating: 3 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2651

(1)

COA / SDS

Inhibitor of JNK signaling

Discontinued Product

2651 has been discontinued. View all JNK/c-jun Inhibitors products.

Key Product Details

Description:	Inhibitor of JNK signaling
Chemical Name:	6-Phenylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide
Purity:	≥99% (HPLC)
Molecular Weight:	280.33

View Full Technical Details for AEG 3482

Technical Data
Citations / Reviews (1)

Biological Activity for AEG 3482

AEG 3482 is an inhibitor of c-jun N-terminal kinase (JNK) signaling. Binds Hsp90 and facilitates HSF1 release, induces expression of Hsp70, which in turn blocks JNK activation and JNK-dependent apoptosis. Antiapoptotic; inhibits NGF withdrawal-induced death in SCG neurons (EC₅₀ = 20 μM).

Compound Libraries for AEG 3482

AEG 3482 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for AEG 3482

M. Wt	280.33
Formula	C₁₀H₈N₄O₂S₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	63735-71-7
PubChem ID	698112
InChi Key	MQUYTXDAVCOCMX-UHFFFAOYSA-N
Smiles	NS(=O)(=O)C1=NN2C=C(N=C2S1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for AEG 3482

References are publications that support the biological activity of the product.

Salehi AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70. Chem.Biol. 2006 PMID: 16492569
Gallo Targeting HSP90 to halt neurodegeneration. Chem.Biol. 2006 PMID: 16492558