AF 12198

Name: AF 12198
Brand: Tocris Bioscience
SKU: 1793
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1793

(1)

Citations (5)

COA / SDS

Potent, selective human type I IL-1 receptor antagonist

Key Product Details

Description:	Potent, selective human type I IL-1 receptor antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	1895.14

View Full Technical Details for AF 12198

Technical Data
Citations / Reviews (1)

Biological Activity for AF 12198

AF 12198 is a potent and selective antagonist for the human type I interleukin-1 (IL-1) receptor (IC₅₀ values are 8 nM, > 6.7 mM and > 200 mM for human type I, human type II and murine type I IL-1 receptors respectively). Blocks IL-1-induced expression of ICAM-1 and E-selectin in HUVECs and IL-1β induction of IL-8 in human dermal fibroblasts. Reduces IL-1β-induced IL-6 production and exhibits anti-inflammatory activity in vivo.

Technical Data for AF 12198

M. Wt	1895.14
Formula	C₉₆H₁₂₃N₁₉O₂₂
Single Letter Sequence	FEWTPGWYQXYALPL (Modifications: Phe-1 = N-terminal Ac, X = Aze, Leu-15 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	185413-30-3
PubChem ID	90488713
InChi Key	VASLMBMCJADVGR-BRPRRQPRSA-N
Smiles	CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)C1CCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC1=CC=CC=C1)NC(C)=O)[C@@H](C)O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AF 12198

Solubility

Soluble to 1mg/ml in 10% ethanol/PBS

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References for AF 12198

References are publications that support the biological activity of the product.

Akeson AF12198, a novel low molecular weight antagonist, selectively binds the human type I interleukin (IL)-1 receptor and blocks in vivo responses to IL-1. J.Biol.Chem. 1996 PMID: 8940020
Aimbire Low level laser therapy (LLLT) decreases pulmonary microvascular leakage, neutrophil influx and IL-1β levels in airway and lung from rat subjected to LPS-induced inflammation. Inflammation 2008 PMID: 18421573