AG 1478 hydrochloride

Name: AG 1478 hydrochloride
Brand: Tocris Bioscience
SKU: 1276
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1276

(2)

Citations (28)

COA / SDS

Highly potent EGFR-kinase inhibitor

Key Product Details

Description:	Highly potent EGFR-kinase inhibitor
Alternative Names:	Tyrphostin AG 1478
Chemical Name:	N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinanine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	352.22

View Full Technical Details for AG 1478 hydrochloride

Technical Data
Citations / Reviews (2)

Biological Activity for AG 1478 hydrochloride

AG 1478 hydrochloride is a potent and selective inhibitor of epidermal growth factor receptor kinase (IC₅₀ values 3 nM for EGFR and > 100 μM for ErbB2 and PDGFR). Inhibits proliferation of NCI-H2170 NSCLC cells in vitro (IC₅₀ = 1 μM).

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data for AG 1478 hydrochloride

M. Wt	352.22
Formula	C₁₆H₁₄ClN₃O₂.HCl
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	170449-18-0
PubChem ID	3035187
InChi Key	WDJDYIUSDDVWKB-UHFFFAOYSA-N
Smiles	ClC1=CC(NC2=NC=NC3=C2C=C(OC)C(OC)=C3)=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AG 1478 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	3.52	10 with gentle warming

Preparing Stock Solutions for AG 1478 hydrochloride

The following data is based on the product molecular weight 352.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.39 mL	141.96 mL	283.91 mL
0.5 mM	5.68 mL	28.39 mL	56.78 mL
1 mM	2.84 mL	14.20 mL	28.39 mL
5 mM	0.57 mL	2.84 mL	5.68 mL

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References for AG 1478 hydrochloride

References are publications that support the biological activity of the product.

Levitzki and Gazit Tyrosine kinase inhibition: an approach to drug development. Science 1995 PMID: 7892601
Han Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors. Cancer Res. 1996 PMID: 8752145
Puri and Salgia Synergism of EGFR and c-Met pathways, cross-talk and inhibition, in non-small cell lung cancer. J.Carcinog. 2008 PMID: 19240370
Eguchi Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells. J.Biol.Chem. 1998 PMID: 9535870