AG 825

Tocris Bioscience, part of Bio-Techne | Catalog # 1555

(1)

Citations (17)

COA / SDS

Selective ErbB2 inhibitor

Key Product Details

Description:	Selective ErbB2 inhibitor
Alternative Names:	Tyrphostin AG 825
Chemical Name:	3-[3-[(2-Benzothiazolylthio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano-2-propenamide
Molecular Weight:	397.47

View Full Technical Details for AG 825

Technical Data
Citations / Reviews (1)

Biological Activity for AG 825

AG 825 is a selective ErbB2 inhibitor (IC₅₀ values are 0.15 and 19 μM at ErbB2 and ErbB1 respectively). Preferentially triggers p38 MAP kinase-dependent apoptosis in androgen-independent prostate cancer cells.

Technical Data for AG 825

M. Wt	397.47
Formula	C₁₉H₁₅N₃O₃S₂
Storage	Store at +4°C
CAS Number	149092-50-2
PubChem ID	6091659
InChi Key	KXDONFLNGBQLTN-WUXMJOGZSA-N
Smiles	COC1=CC(\C=C(/C#N)C(N)=O)=CC(CSC2=NC3=C(S2)C=CC=C3)=C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AG 825

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	39.75	100

Preparing Stock Solutions for AG 825

The following data is based on the product molecular weight 397.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.52 mL	12.58 mL	25.16 mL
5 mM	0.50 mL	2.52 mL	5.03 mL
10 mM	0.25 mL	1.26 mL	2.52 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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Reconstitution Calculator

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References for AG 825

References are publications that support the biological activity of the product.

Murillo Tyrphostin AG825 triggers p38 mitogen-activated protein kinase-dependent apoptosis in androgen-independent prostate cancer cells C4 and C4-21. Cancer Res. 2001 PMID: 11606371
Osherov Selective inhibition of the epidermal growth factor and HER2/Neu receptors by tyrphostins. J.Biol.Chem. 1993 PMID: 8098709
Gazit Tyrphostins. 3. Structure-activity relationship studies of α-substituted benzylidenemalononitrile 5-S-aryltyrphostins. J.Med.Chem. 1993 PMID: 7902440