AGN 192403 hydrochloride

Name: AGN 192403 hydrochloride
Brand: Tocris Bioscience
SKU: 1072

Tocris Bioscience, part of Bio-Techne | Catalog # 1072

Citations (3)

COA / SDS

I1 selective ligand

Key Product Details

Chemical Name:	(±)-2-endo-Amino-3-exo-isopropylbicyclo[2.2.1]heptane hydrochloride
Molecular Weight:	189.73 kDa

View Full Technical Details for AGN 192403 hydrochloride

Technical Data
Citations

Biological Activity for AGN 192403 hydrochloride

AGN 192403 hydrochloride is an i₁ imidazoline binding site selective ligand with a potency at I₁ comparable to moxonidine, but devoid of affinity for adrenoceptors and the I₂ binding site. Causes none of the physiological responses associated with the I₁ binding site in animal models. Also binds TMED9 cargo receptor. Releases MUC1-fs from TMED9 containing vesicles in kidney cells bearing MUC1 gene mutation

Technical Data for AGN 192403 hydrochloride

M. Wt	189.73 kDa
Formula	C₁₀H₁₉N.HCl
Storage	Store at RT
CAS Number	1021868-90-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AGN 192403 hydrochloride

Solubility

Soluble Soluble to 100 mM in water

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References for AGN 192403 hydrochloride

References are publications that support the biological activity of the product.

Fox JT, Sakamuru S, Huang R High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. 2012 PMID: 22431602
Mukaddam-Daher et al. Receptors involved in moxonidine-stimulated strial natriuretic peptide released from isolated normotensive rat hearts. Eur.J.Pharmacol., 2006;541:73 PMID: 16774751
Raasch et al. Agmatine, an endogenous ligand at imidazoline binding sites, does not antagonize the clonidine-mediated blood pressure reaction. Br.J.Pharmacol., 2002;135:663 PMID: 11834614
Munk et al. Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline₁ receptor specific agent. J.Med.Chem., 1996;39:1193 PMID: 8632424
Dvela-Levitt Small molecule targets TMED9 and promotes lysosomal degradation to reverse proteinopathy. Cell, 2019;178:521 PMID: 31348885