AGN 193109

Name: AGN 193109
Brand: Tocris Bioscience
SKU: 5758
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5758

(1)

Citations (23)

COA / SDS

High affinity pan-RAR antagonist

Key Product Details

Description:	High affinity pan-RAR antagonist
Chemical Name:	4-[2-[5,6-Dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	392.49

View Full Technical Details for AGN 193109

Technical Data
Citations / Reviews (1)

Biological Activity for AGN 193109

AGN 193109 is a high affinity pan-retinoic acid receptor (RAR) antagonist (K_d values are 2, 2 and 3 nM at RARα, RARβ and RARγ, respectively). Exhibits no significant affinity for retinoic X receptors. AGN 193109 promotes the differentiation from mouse embryonic stem cells into paraxial mesoderm. AGN 193109 suppresses primary human cardiovascular smooth muscle cell calcification.

AGN 193109 synthesized to Ancillary Material Grade also available.

Compound Libraries for AGN 193109

AGN 193109 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AGN 193109

M. Wt	392.49
Formula	C₂₈H₂₄O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	171746-21-7
PubChem ID	177238
InChi Key	NCEQLLNVRRTCKJ-UHFFFAOYSA-N
Smiles	CC(CC=C1C2=CC=C(C)C=C2)(C)C(C1=C3)=CC=C3C#CC4=CC=C(C(O)=O)C=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AGN 193109

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	3.92	10 with gentle warming

Preparing Stock Solutions for AGN 193109

The following data is based on the product molecular weight 392.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.48 mL	127.39 mL	254.78 mL
0.5 mM	5.10 mL	25.48 mL	50.96 mL
1 mM	2.55 mL	12.74 mL	25.48 mL
5 mM	0.51 mL	2.55 mL	5.10 mL

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References for AGN 193109

References are publications that support the biological activity of the product.

Rogers Retinoids repress human cardiovascular cell calcification with evidence for distinct selective retinoid modulator effects. Arterioscler.Thromb.Vasc.Biol. 2020 PMID: 31852220
Russell Inverse agonism of retinoic acid receptors directs epiblast cells into the paraxial mesoderm lineage. Stem Cell Res. 2018 PMID: 29807258
Levi Saturated fatty acids regulate retinoic acid signalling and suppress tumorigenesis by targeting fatty acid-binding protein 5 Nat.Commun. 2015 PMID: 26592976
Jaurena Zic1 controls placode progenitor formation non-cell autonomously by regulating retinoic acid production and transport. Nat.Commun. 2015 PMID: 26101153
Agarwal AGN193109 is a highly effective antagonist of retinoid action in human ectocervical epithelial cells. J.Biol.Chem. 1996 PMID: 8647816