AIM 100

Name: AIM 100
Brand: Tocris Bioscience
SKU: 4946
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4946

(1)

Citations (8)

COA / SDS

Potent and selective Ack1 (TNK2) inhibitor

Key Product Details

Description:	Potent and selective Ack1 (TNK2) inhibitor
Chemical Name:	5,6-Diphenyl-N-[[(2S)-tetrahydro-2-furanyl]methyl]furo[2,3-d]pyrimidin-4-amine
Purity:	≥98% (HPLC)
Molecular Weight:	371.43

View Full Technical Details for AIM 100

Technical Data
Citations / Reviews (1)

Biological Activity for AIM 100

AIM 100 is a potent Ack1 (TNK2) inhibitor (IC₅₀ = 22 nM). Exhibits selectivity for Ack1 over ABL1, BTK, Lck and LYN; exhibits no inhibition of 25 other kinases. Suppresses phosphorylation of Tyr267 of the androgen receptor in prostate cancer cells. Also suppresses growth of radioresistant castration-resistant prostate cancer in xenograft tumors in mice. Also promotes DAT endocytosis and oligomerization.

Compound Libraries for AIM 100

AIM 100 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for AIM 100

M. Wt	371.43
Formula	C₂₃H₂₁N₃O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	873305-35-2
PubChem ID	11501591
InChi Key	XNFHHOXCDUAYSR-SFHVURJKSA-N
Smiles	C1(C(C4=CC=CC=C4)=C(C5=CC=CC=C5)O3)=C3N=CN=C1NC[C@H]2OCCC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AIM 100

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	37.14	100
	ethanol	37.14	100

Preparing Stock Solutions for AIM 100

The following data is based on the product molecular weight 371.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.69 mL	13.46 mL	26.92 mL
5 mM	0.54 mL	2.69 mL	5.38 mL
10 mM	0.27 mL	1.35 mL	2.69 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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References for AIM 100

References are publications that support the biological activity of the product.

Mahajan Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity. Prostate 2010 PMID: 20623637
Sorkina Small molecule induced oligomerization, clustering and clathrin-independent endocytosis of the dopamine transporter. Elife. 2018 PMID: 29630493
Mahajan Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer. J.Biol.Chem. 2012 PMID: 22566699