AK 7

Name: AK 7
Brand: Tocris Bioscience
SKU: 4754

Tocris Bioscience, part of Bio-Techne | Catalog # 4754

Citations (8)

COA / SDS

Selective SIRT2 inhibitor; brain penetrant

Key Product Details

Description:	Selective SIRT2 inhibitor; brain penetrant
Chemical Name:	N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	437.35

View Full Technical Details for AK 7

Technical Data
Citations

Biological Activity for AK 7

AK 7 is a selective SIRT2 inhibitor (IC₅₀ = 15.5 μM); displays no effect on SIRT1 or SIRT3. Decreases neuronal cholesterol levels; improves motor function and ameliorates brain atrophy in a mouse model of Huntington's disease. Brain penetrant.

Compound Libraries for AK 7

AK 7 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for AK 7

M. Wt	437.35
Formula	C₁₉H₂₁BrN₂O₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	420831-40-9
PubChem ID	1328033
InChi Key	IYAYHZZWYNXHEQ-UHFFFAOYSA-N
Smiles	O=C(NC2=CC(Br)=CC=C2)C1=CC(S(N3CCCCCC3)(=O)=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AK 7

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	43.73	100

Preparing Stock Solutions for AK 7

The following data is based on the product molecular weight 437.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.29 mL	11.43 mL	22.86 mL
5 mM	0.46 mL	2.29 mL	4.57 mL
10 mM	0.23 mL	1.14 mL	2.29 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for AK 7

References are publications that support the biological activity of the product.

Taylor A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase. ACS Chem.Biol. 2011 PMID: 21370928
Chopra The sirtuin inhibitor AK-7 is neuroprotective in Huntington's disease mouse models. Cell Rep. 2012 PMID: 23200855