Alexidine dihydrochloride

Name: Alexidine dihydrochloride
Brand: Tocris Bioscience
SKU: 3979

Tocris Bioscience, part of Bio-Techne | Catalog # 3979

Citations (1)

COA / SDS

Selective inhibitor of PTPMT1

Key Product Details

Description:	Selective inhibitor of PTPMT1
Chemical Name:	N,N''-Bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide dihydrochloride
Molecular Weight:	581.71

View Full Technical Details for Alexidine dihydrochloride

Technical Data
Citations

Biological Activity for Alexidine dihydrochloride

Alexidine dihydrochloride is a selective inhibitor of protein tyrosine phosphatases localized to mitochondrion 1 (PTPMT1) (IC₅₀ = 1.08 μM in vitro). Stimulates increased insulin secretion by β-cells in rat pancreatic islets. Displays antitcancer properties in FaDu cells. Also preserves functional hematopoietic stem cells ex vivo.

Compound Libraries for Alexidine dihydrochloride

Alexidine dihydrochloride is also offered as part of the Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for Alexidine dihydrochloride

M. Wt	581.71
Formula	C₂₆H₅₆N₁₀.2HCl
Storage	Desiccate at -20°C
CAS Number	1715-30-6
PubChem ID	102678
InChi Key	BRJJFBHTDVWTCJ-UHFFFAOYSA-N
Smiles	N=C(NC(NCC(CC)CCCC)=N)NCCCCCCNC(NC(NCC(CC)CCCC)=N)=N.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Alexidine dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	58.17	100
	ethanol	58.17	100

Preparing Stock Solutions for Alexidine dihydrochloride

The following data is based on the product molecular weight 581.71.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.72 mL	8.60 mL	17.19 mL
5 mM	0.34 mL	1.72 mL	3.44 mL
10 mM	0.17 mL	0.86 mL	1.72 mL
50 mM	0.03 mL	0.17 mL	0.34 mL

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Reconstitution Calculator

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References for Alexidine dihydrochloride

References are publications that support the biological activity of the product.

Doughty-Shenton Pharmacological targeting of the mitochondrial phosphatase PTPMT1. J.Pharmacol.Exp.Ther. 2010 PMID: 20167843
Liu Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism. Blood 2015 PMID: 25593337
Yip Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent. Mol.Cancer Ther. 2006 PMID: 16985057