Altanserin hydrochloride

Name: Altanserin hydrochloride
Brand: Tocris Bioscience
SKU: 1809

Tocris Bioscience, part of Bio-Techne | Catalog # 1809

Citations (2)

COA / SDS

5-HT2A receptor antagonist

Key Product Details

Description:	5-HT_2A receptor antagonist
Chemical Name:	3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	447.95

View Full Technical Details for Altanserin hydrochloride

Technical Data
Citations

Biological Activity for Altanserin hydrochloride

Altanserin hydrochloride is a potent and selective 5-HT_2A receptor antagonist (K_i values are 0.13, 4.55, 40, 62 and 1570 nM at 5-HT_2A, α₁, 5-HT_2C, D₂ and 5-HT_1A respectively). Centrally active following systemic administration in vivo.

Compound Libraries for Altanserin hydrochloride

Altanserin hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Altanserin hydrochloride

M. Wt	447.95
Formula	C₂₂H₂₂FN₃O₂S.HCl
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	1135280-78-2
PubChem ID	24978536
InChi Key	JFPPLMAMMZZOEA-UHFFFAOYSA-N
Smiles	Cl.FC1=CC=C(C=C1)C(=O)C1CCN(CCN2C(=S)NC3=CC=CC=C3C2=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Altanserin hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	8.96	20 with gentle warming

Preparing Stock Solutions for Altanserin hydrochloride

The following data is based on the product molecular weight 447.95.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.16 mL	55.81 mL	111.62 mL
1 mM	2.23 mL	11.16 mL	22.32 mL
2 mM	1.12 mL	5.58 mL	11.16 mL
10 mM	0.22 mL	1.12 mL	2.23 mL

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References for Altanserin hydrochloride

References are publications that support the biological activity of the product.

Sietnick Involvement of 5-HT₂ receptors in the LSD- and L-5-HTP-induced suppression of lordotic behavior in the female rat. J.Neural Transm. 1985 PMID: 3872342
Kennett Evidence that 5-HT_2C receptor antagonists are anxiolytic in the rat Geller-Seifter model of anxiety. Psychopharmacology 1994 PMID: 7846211
Koenig Stimulation of corticosterone and β-endorphin secretion in the rat by selective 5-HT receptor subtype activation. Eur.J.Pharmacol. 1987 PMID: 2956114
Herth Synthesis and in vitro affinities of various MDL 100907 derivatives as potential ¹⁸F-radioligands for 5-HT_2A receptor imaging with PET. Bioorg.Med.Chem. 2009 PMID: 19329329