AM 630

Tocris Bioscience, part of Bio-Techne | Catalog # 1120

COA / SDS

Selective CB2 inverse agonist

Key Product Details

Description:	Selective CB₂ inverse agonist
Chemical Name:	6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanone
Purity:	≥98% (HPLC)
Molecular Weight:	504.37

View Full Technical Details for AM 630

Technical Data
Citations

Biological Activity for AM 630

AM 630 is a CB₂ inverse agonist (K_i = 31.2 nM) that displays 165-fold selectivity over CB₁ receptors. Behaves as a weak partial/inverse agonist at CB₁ receptors.

Technical Data for AM 630

M. Wt	504.37
Formula	C₂₃H₂₅IN₂O₃
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	164178-33-0
PubChem ID	4302963
InChi Key	JHOTYHDSLIUKCJ-UHFFFAOYSA-N
Smiles	COC1=CC=C(C=C1)C(=O)C1=C(C)N(CCN2CCOCC2)C2=CC(I)=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AM 630

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	50.44	100

Preparing Stock Solutions for AM 630

The following data is based on the product molecular weight 504.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.98 mL	9.91 mL	19.83 mL
5 mM	0.40 mL	1.98 mL	3.97 mL
10 mM	0.20 mL	0.99 mL	1.98 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

Molarity Calculator

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Reconstitution Calculator

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References for AM 630

References are publications that support the biological activity of the product.

Ross Agonist-inverse agonist characterization at CB₁ and CB₂ cannabinoid receptors of L759633, L759656 and AM630. Br.J.Pharmacol. 1999 PMID: 10188977
Hosohata AM630 antagonism of cannabinoid-stimulated [³⁵S]GTPγS binding in the mouse brain. Eur.J.Pharmacol. 1997 PMID: 9083796
Landsman AM630 is an inverse agonist at the human cannabinoid CB₁ receptor. Life Sci. 1998 PMID: 9496703
Hosohata AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain. Life Sci. 1997 PMID: 9284087