AMG 18 hydrochloride

Name: AMG 18 hydrochloride
Brand: Tocris Bioscience
SKU: 6166

Tocris Bioscience, part of Bio-Techne | Catalog # 6166

Citations (3)

COA / SDS

Potent and selective IRE1α inhibitor

Key Product Details

Chemical Name:	2-Chloro-N-[6-methyl-5-[[3-[2-[(3S)-3-piperidinylamino]-4-pyrimidinyl]-2-pyridinyl]oxy]-1-naphthalenyl]benzenesulfonamide hydrochloride
Purity:	≥98%

View Full Technical Details for AMG 18 hydrochloride

Technical Data
Citations

Biological Activity for AMG 18 hydrochloride

AMG 18 hydrochloride is a potent and selective IRE1α inhibitor (IC₅₀ values are 13 and 99 nM for recombinant and cellular IRE1α, respectively). Exhibits selectivity for IRE1α in a panel of over 100 other kinases.

Technical Data for AMG 18 hydrochloride

Formula	C₃₁H₂₉ClN₆O₃S.HCl
Storage	Store at -20°C
Purity	≥98%
CAS Number	2250019-92-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AMG 18 hydrochloride

Solubility

Soluble Soluble to 100 mM in water and to 100 mM in DMSO

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References for AMG 18 hydrochloride

References are publications that support the biological activity of the product.

Harrington et al. Unfolded protein response in cancer: IRE1α inhibition by selective kinase ligands does not impair tumor cell viability. ACS Med.Chem.Lett., 2014;6:68 PMID: 25589933

AMG 18 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 6166

Key Product Details

Biological Activity for AMG 18 hydrochloride

Technical Data for AMG 18 hydrochloride

Solubility for AMG 18 hydrochloride

Dilution Calculator

Reconstitution Calculator

References for AMG 18 hydrochloride

Product Documents for AMG 18 hydrochloride

COA

Certificate of Analysis

SDS

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