AMG 517

Name: AMG 517
Brand: Tocris Bioscience
SKU: 5995
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5995

(1)

Citations (6)

COA / SDS

Potent TRPV1 antagonist

Key Product Details

Description:	Potent TRPV1 antagonist
Chemical Name:	N-[4-[[6-[4-(Trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2-benzothiazolyl]acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	430.41

View Full Technical Details for AMG 517

Technical Data
Citations / Reviews (1)

Biological Activity for AMG 517

AMG 517 is a potent TRPV1 antagonist (IC₅₀ = 0.9 nM). Inhibits capsaican-induced flinching and reverses analgesia in an inflammatory pain model in rats. Orally bioavailable.

Compound Libraries for AMG 517

AMG 517 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AMG 517

M. Wt	430.41
Formula	C₂₀H₁₃F₃N₄O₂S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	659730-32-2
PubChem ID	16007367
InChi Key	YUTIXVXZQIQWGY-UHFFFAOYSA-N
Smiles	O=C(NC(S1)=NC(C1=CC=C2)=C2OC3=NC=NC(C4=CC=C(C(F)(F)F)C=C4)=C3)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AMG 517

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.3	10

Preparing Stock Solutions for AMG 517

The following data is based on the product molecular weight 430.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.23 mL	116.17 mL	232.34 mL
0.5 mM	4.65 mL	23.23 mL	46.47 mL
1 mM	2.32 mL	11.62 mL	23.23 mL
5 mM	0.46 mL	2.32 mL	4.65 mL

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Reconstitution Calculator

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References for AMG 517

References are publications that support the biological activity of the product.

Wang Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties. J.Med.Chem. 2007 PMID: 17585751
Doherty Novel vanilloid receptor-1 antagonists: 2. Structure-activity relationships of 4-oxopyrimidines leading to the selection of a clinical candidate. J.Med.Chem. 2007 PMID: 17585750
Gavva Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade. J.Pharmacol.Exp.Ther. 2007 PMID: 17652633