AMG 9810

Name: AMG 9810
Brand: Tocris Bioscience
SKU: 2316
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2316

(1)

Citations (80)

COA / SDS

Potent and selective TRPV1 competitive antagonist

Key Product Details

Description:	Potent and selective TRPV1 competitive antagonist
Chemical Name:	(2E)-N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-propenamide
Purity:	≥98% (HPLC)
Molecular Weight:	337.42

View Full Technical Details for AMG 9810

Technical Data
Citations / Reviews (1)

Biological Activity for AMG 9810

AMG 9810 is a potent and selective, competitive vanilloid TRPV1 receptor antagonist (IC₅₀ = 17 nM). Inhibits capsaicin-, proton-, heat- and endogenous ligand-induced activation of human and rat recombinant TRPV1 receptors. Displays antihyperalgesic properties in a rat model of inflammatory pain.

Technical Data for AMG 9810

M. Wt	337.42
Formula	C₂₁H₂₃NO₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	545395-94-6
PubChem ID	680502
InChi Key	GZTFUVZVLYUPRG-IZZDOVSWSA-N
Smiles	CC(C)(C)C1=CC=C(C=C1)\C=C\C(=O)NC1=CC=C2OCCOC2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AMG 9810

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	16.87	50
	ethanol	33.74	100

Preparing Stock Solutions for AMG 9810

The following data is based on the product molecular weight 337.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.96 mL	14.82 mL	29.64 mL
5 mM	0.59 mL	2.96 mL	5.93 mL
10 mM	0.30 mL	1.48 mL	2.96 mL
50 mM	0.06 mL	0.30 mL	0.59 mL

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References for AMG 9810

References are publications that support the biological activity of the product.

Gavva AMG 9810 [(E)-3-(4-t-Butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. J.Pharmacol.Exp.Ther. 2005 PMID: 15615864
Mouchbahani-Constance Lionfish venom elicits pain predominantly through the activation of nonpeptidergic nociceptors. Pain. 2018 PMID: 29965829
Doherty Discovery of potent, orally available vanilloid receptor-1 antagonists. Structure-activity relationship of N-aryl cinnamides. J.Med.Chem. 2005 PMID: 15634002