Amyloid β-Peptide (1-42) (human)

Name: Amyloid β-Peptide (1-42) (human)
Brand: Tocris Bioscience
SKU: 1428
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1428

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Citations (21)

COA / SDS

Predominant amyloid β-protein fragment

Key Product Details

Description:	Predominant amyloid β-protein fragment
Purity:	≥95% (HPLC)
Molecular Weight:	4514.08

View Full Technical Details for Amyloid β-Peptide (1-42) (human)

Technical Data
Citations / Reviews (1)

Biological Activity for Amyloid β-Peptide (1-42) (human)

Amyloid β-Peptide (1-42) (human) is a human form of the predominant amyloid β-peptide found in the brains of patients with Alzheimer's disease. Downregulates bcl-2 and increases the levels of bax. Neurotoxic.

Control Peptide also available.

Technical Data for Amyloid β-Peptide (1-42) (human)

M. Wt	4514.08
Formula	C₂₀₃H₃₁₁N₅₅O₆₀S
Single Letter Sequence	DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	107761-42-2
PubChem ID	16135558
InChi Key	DZHSAHHDTRWUTF-SIQRNXPUSA-N
Smiles	[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Amyloid β-Peptide (1-42) (human)

Solubility

Soluble to 1mg/ml in 50mM Tris buffer

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References for Amyloid β-Peptide (1-42) (human)

References are publications that support the biological activity of the product.

Paradis Amyloid beta peptide of Alzheimer's disease downregulates bcl-2 and upregulates bax expression in human neurons. J.Neurosci. 1996 PMID: 8922409
Van Nostrand Amyloid β-protein induces the cerebrovascular cellular pathology of Alzheimer's disease and related disorders. Ann.N.Y.Acad.Sci. 1996 PMID: 8624102
Glenner and Wong Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem.Biophys.Res.Commun. 1984 PMID: 6375662