Anacardic acid

Name: Anacardic acid
Brand: Tocris Bioscience
SKU: 3084

Tocris Bioscience, part of Bio-Techne | Catalog # 3084

Citations (10)

COA / SDS

Noncompetitive PCAF/p300 inhibitor

Key Product Details

Description:	Noncompetitive PCAF/p300 inhibitor
Chemical Name:	2-Hydroxy-6-pentadecylbenzoic acid
Purity:	≥97% (HPLC)
Molecular Weight:	348.52

View Full Technical Details for Anacardic acid

Technical Data
Citations

Biological Activity for Anacardic acid

Anacardic acid is a noncompetitive inhibitor of PCAF and p300 histone acetyltransferase (HAT) activity (IC₅₀ values are ~5.0 and ~8.5 μM respectively). Inhibits NF-κB activation. Also reported to selectively activate Aurora kinase A-mediated phosphorylation of histone H3 and to inhibit protein SUMOylation. Exhibits antitumor, antimicrobial and antioxidant activity. Also promotes cardiomyocyte differentiation from mESCs.

Technical Data for Anacardic acid

M. Wt	348.52
Formula	C₂₂H₃₆O₃
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	16611-84-0
PubChem ID	167551
InChi Key	ADFWQBGTDJIESE-UHFFFAOYSA-N
Smiles	OC1=C(C(O)=O)C(CCCCCCCCCCCCCCC)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Anacardic acid

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	34.85	100
	ethanol	17.43	50

Preparing Stock Solutions for Anacardic acid

The following data is based on the product molecular weight 348.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.87 mL	14.35 mL	28.69 mL
5 mM	0.57 mL	2.87 mL	5.74 mL
10 mM	0.29 mL	1.43 mL	2.87 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

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References for Anacardic acid

References are publications that support the biological activity of the product.

Re Anacardic acid and thyroid hormone enhance cardiomyocytes production from undifferentiated mouse ES cells along functionally distinct pathways. Endocrine 2016 PMID: 26547215
Fukuda Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate. Chem.Biol. 2009 PMID: 19246003
Balasubramanyam Small molecule modulators of histone acetyltransferase p300. J.Biol.Chem. 2003 PMID: 12624111
Cui Histone acetyltransferase inhibitor anacardic acid causes changes in global gene expression during in vitro Plasmodium falciparum development. Eurkaryot.Cell
Sung Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-κB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the Blood 2008 PMID: 18349320
Kishore Specific small molecule activator of aurora kinase A induces autophosphorylation in a cell-free system. J.Med.Chem. 2008 PMID: 18215015