Ani 9

Name: Ani 9
Brand: Tocris Bioscience
SKU: 6076

Tocris Bioscience, part of Bio-Techne | Catalog # 6076

Citations (24)

COA / SDS

Potent and selective TMEM16A (Anoctamin-1; ANO1) blocker

Key Product Details

Description:	Potent and selective TMEM16A (Anoctamin-1; ANO1) blocker
Chemical Name:	2-(4-Chloro-2-methylphenoxy)-N'-(2-methoxybenzylidene)acetohydrazide
Purity:	≥98% (HPLC)
Molecular Weight:	332.78

View Full Technical Details for Ani 9

Technical Data
Citations

Biological Activity for Ani 9

Ani 9 is a potent and selective TMEM16A (Anoctamin-1; ANO1) blocker (IC₅₀ = 77 nM). Displays no effect on ANO2 activity (at 10 μM). Also exhibits no effect on intracellular calcium signaling or CFTR and ENaC channel activity (at 30 μM).

Technical Data for Ani 9

M. Wt	332.78
Formula	C₁₇H₁₇ClN₂O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	356102-14-2
PubChem ID	9556542
InChi Key	KDALDZRKOBJXIE-VXLYETTFSA-N
Smiles	COC1=C(C=CC=C1)/C=N/NC(COC2=C(C=C(C=C2)Cl)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ani 9

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	33.28	100

Preparing Stock Solutions for Ani 9

The following data is based on the product molecular weight 332.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.00 mL	15.02 mL	30.05 mL
5 mM	0.60 mL	3.00 mL	6.01 mL
10 mM	0.30 mL	1.50 mL	3.00 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

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References for Ani 9

References are publications that support the biological activity of the product.

Seo Ani9, a novel potent small-molecule ANO1 inhibitor with negligible effect on ANO2. PLoS One 2016 PMID: 27219012