AP 811

Name: AP 811
Brand: Tocris Bioscience
SKU: 5498
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5498

(1)

Citations (7)

COA / SDS

High affinity, selective NPR3 antagonist

Key Product Details

Description:	High affinity, selective NPR3 antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	915.1

View Full Technical Details for AP 811

Technical Data
Citations / Reviews (1)

Biological Activity for AP 811

AP 811 is a high affinity, selective ANP clearance receptor (NPR3) antagonist (K_i = 0.45 nM). Exhibits >20,000-fold selectivity for NPR3 over NPR1. Inhibits ANP-stimulated Na⁺/K⁺ pump activity in rabbit ventricular cardiomyocytes in vitro. Also blocks proliferation of rodent neonatal cardiomyocytes seen at low ANP concentrations in vitro.

Technical Data for AP 811

M. Wt	915.1
Formula	C₄₆H₆₆N₁₂O₈
Single Letter Sequence	RIDR (Modifications: Arg-1 = N²-[4-(2-Naphthoylamino)phenylacetyl], Arg-4 = C-terminal (S)-2-methylbutylamide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	124833-45-0
PubChem ID	44301714
InChi Key	UNMJSSQZDQBGDS-OCFLPWLCSA-N
Smiles	CC[C@H](C)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CC1=CC=C(NC(=O)C2=CC3=C(C=CC=C3)C=C2)C=C1)[C@@H](C)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AP 811

Solubility

Soluble to 1mg/ml in water

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for AP 811

References are publications that support the biological activity of the product.

William Natriuretic peptides stimulate the cardiac sodium pump via NPR-C-coupled NOS activation. Am.J.Physiol.Cell Physiol. 2008 PMID: 18272821
Becker Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development. Development 2014 PMID: 24353062
Veale The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1. Bioorg.Med.Chem.Lett. 2000 PMID: 10987424