Aphidicolin

Name: Aphidicolin
Brand: Tocris Bioscience
SKU: 5736

Tocris Bioscience, part of Bio-Techne | Catalog # 5736

Citations (14)

COA / SDS

DNA polymerase α, δ and ε inhibitor

Key Product Details

Description:	DNA polymerase α, δ and ε inhibitor
Chemical Name:	(3R,4R,4aR,6aS,8R,9R,11aS,11bS)-Tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol
Purity:	≥98% (HPLC)
Molecular Weight:	338.48

View Full Technical Details for Aphidicolin

Technical Data
Citations

Biological Activity for Aphidicolin

Aphidicolin is a DNA polymerase α, δ and ε inhibitor. Exhibits selectivity over DNA polymerase β and γ. Antimitotic, antibiotic and antiviral.

Technical Data for Aphidicolin

M. Wt	338.48
Formula	C₂₀H₃₄O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	38966-21-1
PubChem ID	457964
InChi Key	NOFOAYPPHIUXJR-APNQCZIXSA-N
Smiles	OC[C@@]1(O)CC[C@@]23[C@](CC[C@]4([H])[C@]3(C)CC[C@@H](O)[C@@]4(C)CO)([H])C[C@@H]1C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Aphidicolin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	8.46	25

Preparing Stock Solutions for Aphidicolin

The following data is based on the product molecular weight 338.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	11.82 mL	59.09 mL	118.18 mL
1.25 mM	2.36 mL	11.82 mL	23.64 mL
2.5 mM	1.18 mL	5.91 mL	11.82 mL
12.5 mM	0.24 mL	1.18 mL	2.36 mL

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Reconstitution Calculator

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References for Aphidicolin

References are publications that support the biological activity of the product.

Bucknall Antiviral effects of aphidicolin, a new antibiotic produced by Cephalosporium aphidicola. Antimicrob.Agents Chemother. 1973 PMID: 4357181
Syväoja DNA polymerases α, δ, and ε: three distinct enzymes from HeLa cells. Proc.Natl.Acad.Sci.U.S.A. 1990 PMID: 1975694
Spadari Control of DNA replication and cell proliferation in eukaryotes by aphidicolin. Toxicol.Pathol. 1984 PMID: 11478315