APY 29

Name: APY 29
Brand: Tocris Bioscience
SKU: 4865

Tocris Bioscience, part of Bio-Techne | Catalog # 4865

Citations (6)

COA / SDS

Inhibits IRE1α autophosphorylation; activates IRE1α endoribonuclease activity

Key Product Details

Description:	Inhibits IRE1α autophosphorylation; activates IRE1α endoribonuclease activity
Chemical Name:	N²-1H-Benzimidazol-6-yl-N⁴-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine
Purity:	≥98% (HPLC)
Molecular Weight:	332.36

View Full Technical Details for APY 29

Technical Data
Citations

Biological Activity for APY 29

APY 29 is an allosteric modulator of IRE1α. Inhibits IRE1α autophosphorylation (IC₅₀ = 280 nM) and activates IRE1α ribonuclease activity.

Compound Libraries for APY 29

APY 29 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for APY 29

M. Wt	332.36
Formula	C₁₇H₁₆N₈
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1216665-49-4
PubChem ID	42627755
InChi Key	WJNBSTLIALIIEW-UHFFFAOYSA-N
Smiles	C1(NC2=CC(NC=N3)=C3C=C2)=NC=CC(NC4=CC(C5CC5)=NN4)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for APY 29

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.24	100
	1eq. HCl	16.62	50

Preparing Stock Solutions for APY 29

The following data is based on the product molecular weight 332.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.01 mL	15.04 mL	30.09 mL
5 mM	0.60 mL	3.01 mL	6.02 mL
10 mM	0.30 mL	1.50 mL	3.01 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

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References for APY 29

References are publications that support the biological activity of the product.

Korennykh The unfolded protein response signals through high-order assembly of Ire1. Nature 2009 PMID: 19079236
Wang Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors. Nat.Chem.Biol. 2012 PMID: 23086298