AR 420626

Name: AR 420626
Brand: Tocris Bioscience
SKU: 6163

Tocris Bioscience, part of Bio-Techne | Catalog # 6163

Citations (3)

COA / SDS

FFA3 agonist

Key Product Details

Description:	FFA3 agonist
Chemical Name:	N-(2,5-Dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	417.29

View Full Technical Details for AR 420626

Technical Data
Citations

Biological Activity for AR 420626

AR 420626 is a FFA3 agonist (pEC₅₀ = 5.74). Inhibits nicotine and serotonin induced changes in motility of isolated muscle strips from rat colon. Also suppresses serotonin-induced fecal output in rats.

Compound Libraries for AR 420626

AR 420626 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AR 420626

M. Wt	417.29
Formula	C₂₁H₁₈Cl₂N₂O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1798310-55-0
PubChem ID	11509934
InChi Key	BYLWSJCOCFUZDH-UHFFFAOYSA-N
Smiles	CC1=C(C(NC2=C(C=CC(Cl)=C2)Cl)=O)C(C3=C(N1)CCCC3=O)C4=CC=CO4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AR 420626

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	20.86	50

Preparing Stock Solutions for AR 420626

The following data is based on the product molecular weight 417.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.79 mL	23.96 mL	47.93 mL
2.5 mM	0.96 mL	4.79 mL	9.59 mL
5 mM	0.48 mL	2.40 mL	4.79 mL
25 mM	0.10 mL	0.48 mL	0.96 mL

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References for AR 420626

References are publications that support the biological activity of the product.

Kaji Free fatty acid receptor 3 activation suppresses neurogenic motility in rat proximal colon. Neurogastroenterol.Motil. 2017 PMID: 28714277
Hudson Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands. Mol Pharmacol. 2014 PMID: 24870406