AR-C 118925XX

Name: AR-C 118925XX
Brand: Tocris Bioscience
SKU: 4890

Tocris Bioscience, part of Bio-Techne | Catalog # 4890

Citations (51)

COA / SDS

Selective and competitive P2Y2 antagonist

Key Product Details

Description:	Selective and competitive P2Y₂ antagonist
Chemical Name:	5-[[5-(2,8-Dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl)-3,4-dihydro-2-oxo-4-thioxo-1(2H)-pyrimidinyl]methyl]-N-2H-tetrazol-5-yl-2-furancarboxamide
Purity:	≥97% (HPLC)
Molecular Weight:	537.59

View Full Technical Details for AR-C 118925XX

Technical Data
Citations

Biological Activity for AR-C 118925XX

AR-C 118925XX is a potent, selective, competitive and reversible P2Y₂ receptor antagonist (pA₂ = 8.43). Inactive against a panel of 37 other receptors at a concentration of 10 μM. AR-C 118925XX inhibits ATP-γS-induced mucin secretion in bronchial epithelial cells (IC₅₀ = 1 μM). Inhibits P2Y₂ receptor-induced β-arrestin translocation in vitro (pA₂ = 37.2-51.3 nM).

Technical Data for AR-C 118925XX

M. Wt	537.59
Formula	C₂₈H₂₃N₇O₃S
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	216657-60-2
PubChem ID	54210200
InChi Key	PVKNPGQAFNALOI-UHFFFAOYSA-N
Smiles	CC(C=C1)=CC2=C1C(C3=CN(CC4=CC=C(C(NC5=NN=NN5)=O)O4)C(NC3=S)=O)C(C=CC(C)=C6)=C6C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AR-C 118925XX

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	53.76	100

Preparing Stock Solutions for AR-C 118925XX

The following data is based on the product molecular weight 537.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.86 mL	9.30 mL	18.60 mL
5 mM	0.37 mL	1.86 mL	3.72 mL
10 mM	0.19 mL	0.93 mL	1.86 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for AR-C 118925XX

References are publications that support the biological activity of the product.

Muoboghare Characterisation of P2Y₂ receptors in human vascular endothelial cells using AR-C118925XX, a competitive and selective P2Y₂ antagonist. Br.J.Pharmacol. 2019 PMID: 31116875
Meghani The design of P2Y₂ antagonists for the treatment of inflammatory diseases. Abstract of papers, 224th ACS National Meeting, Boston, MA
Rafehi Synthesis, characterization, and in vitro evaluation of the selective P2Y₂ receptor antagonist AR-C118925. Purinergic.Signal. 2017 PMID: 27766552
Kemp Nucleotide-mediated mucin secretion from differentiated human bronchial epithelial cells. Am.J.Respir.Cell Mol.Biol. 2004 PMID: 15231488