ARL 17477 dihydrochloride

Name: ARL 17477 dihydrochloride
Brand: Tocris Bioscience
SKU: 3319

Tocris Bioscience, part of Bio-Techne | Catalog # 3319

Citations (3)

COA / SDS

Selective nNOS inhibitor

Key Product Details

Description:	Selective nNOS inhibitor
Chemical Name:	N-[4-[2-[[(3-Chlorophenyl)methyl]amino]ethyl]phenyl]-2-thiophenecarboxamide dihydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	442.83

View Full Technical Details for ARL 17477 dihydrochloride

Technical Data
Citations

Biological Activity for ARL 17477 dihydrochloride

ARL 17477 dihydrochloride is a selective neuronal nitrogen oxide synthase (nNOS) inhibitor (IC₅₀ values are 1 and 17 μM for nNOS and endothelial NOS respectively). Reduces ischemic cell damage after middle cerebral artery (MCA) occlusion in rats. Displays a synergistic neuroprotective effect when combined with either an NMDA or AMPA receptor antagonist.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries for ARL 17477 dihydrochloride

ARL 17477 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ARL 17477 dihydrochloride

M. Wt	442.83
Formula	C₂₀H₂₀ClN₃S.2HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	866914-87-6
PubChem ID	9824646
InChi Key	SOXBYIKSUDXMIE-UHFFFAOYSA-N
Smiles	ClC1=CC=CC(CNCCC2=CC=C(NC(C3=CC=CS3)=N)C=C2)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ARL 17477 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	22.14	50
	DMSO	44.28	100

Preparing Stock Solutions for ARL 17477 dihydrochloride

The following data is based on the product molecular weight 442.83.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.26 mL	11.29 mL	22.58 mL
5 mM	0.45 mL	2.26 mL	4.52 mL
10 mM	0.23 mL	1.13 mL	2.26 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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References for ARL 17477 dihydrochloride

References are publications that support the biological activity of the product.

O'Neill ARL 17477, a selective nitric oxide synthase inhibitor, with neuroprotective effects in animal models of global and focal cerebral ischaemia. Brain Res. 2000 PMID: 10899290
Zhang ARL 17477, a potent and selective neuronal NOS inhibitor decreases infarct volume after transient middle cerebral artery occlusion in rats. J.Cereb.Flow Metab. 1996 PMID: 8964798
Hicks Synergistic neuroprotective effects by combining an NMDA or AMPA receptor antagonist with nitric oxide synthase inhibitors in global cerebral ischaemia. Eur.J.Pharmacol. 1999 PMID: 10554878