ARN 11391

Name: ARN 11391
Brand: Tocris Bioscience
SKU: 7909

Tocris Bioscience, part of Bio-Techne | Catalog # 7909

Citations (1)

COA / SDS

Potentiator of the IP3-gated calcium channel ITPR1

Key Product Details

Description:	Potentiator of the IP3-gated calcium channel ITPR1
Chemical Name:	2-Ethyl-4,5,6,7-tetrahydro-N-[2-[(tetrahydro-2H-pyran-2-yl)methoxy]phenyl]-2H-indazole-3-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	383.49

View Full Technical Details for ARN 11391

Technical Data
Citations

Biological Activity for ARN 11391

ARN 11391 is a potentiator of the IP₃-gated calcium channel ITPR1 (Inositol 1,4,5-trisphosphate (IP₃) receptor type 1). It amplifies intracellular calcium ion signaling by acting directly on ITPR1. ARN 11391 also potentiates calcium signaling in cells expressing mutant ITPR1 which is associated with SCA29, a form of spinocerebellar ataxia.

Technical Data for ARN 11391

M. Wt	383.49
Formula	C₂₂H₂₉N₃O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1214569-31-9
PubChem ID	46969526
InChi Key	WEHYVOUAIUTKKA-UHFFFAOYSA-N
Smiles	O=C(C1=C2C(CCCC2)=NN1CC)NC3=C(OCC4OCCCC4)C=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ARN 11391

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	38.35	100
	ethanol	38.35	100

Preparing Stock Solutions for ARN 11391

The following data is based on the product molecular weight 383.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.61 mL	13.04 mL	26.08 mL
5 mM	0.52 mL	2.61 mL	5.22 mL
10 mM	0.26 mL	1.30 mL	2.61 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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References for ARN 11391

References are publications that support the biological activity of the product.

Genovese Pharmacological potentiators of the calcium signaling cascade identified by high-throughput screening. PNAS Nexus 2022 PMID: 36712939